ReviewClinical ophthalmology (Auckland, N.Z.)2019
Intra-Arterial Thrombolysis for Central Retinal Artery Occlusion.
Review in Clinical ophthalmology (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Thrombolysis for Central Retinal Artery Occlusion in 2020: Time Is Vision!Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2020Pooled it
- The Efficacy and Safety of Prostaglandin E1 in the Management of Ischemic Retinal and Optic Nerve Diseases: A Systematic Review.Neuro-ophthalmology (Aeolus Press) · 2026Review
- Polarization-Sensitive OCT Assessment of Retinal Emboli in Branch Retinal Artery Occlusion: A Pilot Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Management of vision loss associated with complications of cosmetic filler injections.Frontiers in ophthalmology · 2025Review
- Review
- Thrombolytic Therapy for Central Retinal Artery Occlusion in an Academic Multi-Site Stroke Centre.Neuro-ophthalmology (Aeolus Press) · 2024Article
- Progress in central retinal artery occlusion: a narrative review.The Journal of international medical research · 2023Review
- The diagnosis and treatment of central retinal artery occlusion with severe cardio-cerebrovascular disease: a case report.Annals of translational medicine · 2023Article
- Neuroprotection for Nonarteritic Central Retinal Artery Occlusion: Lessons from Acute Ischemic Stroke.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Risk Factors and Treatment Strategy for Retinal Vascular Occlusive Diseases.Journal of clinical medicine · 2022Review
- Bridging a Century-Old Problem: The Pathophysiology and Molecular Mechanisms of HA Filler-Induced Vascular Occlusion (FIVO)-Implications for Therapeutic Interventions.Molecules (Basel, Switzerland) · 2022Review
- Retinal Infarction: A Pilot Study on the Efficacy and Safety of Intravenous Thrombolysis and Underlying Aetiologies.Life (Basel, Switzerland) · 2022Article
- Intravenous lipo-prostaglandin E1 administration for patients with acute central retinal artery occlusion.BMJ open ophthalmology · 2022Article
- Contribution of Orbital Ultrasound to the Diagnosis of Central Retinal Artery Occlusion.Journal of clinical medicine · 2022Article
- Visual complications after coil embolization of internal carotid artery aneurysms at the ophthalmic segment.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021Article
- Retinal emboli after cervicopetrous junction internal carotid artery pseudoaneurysm stenting.American journal of ophthalmology case reports · 2021Article
- Safety and Efficacy of Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion.Korean journal of ophthalmology : KJO · 2021Article
- Invited Discussion on: "An Efficacy and Safety Study of Intraarterial Recanalization of Occluded Ophthalmic Arteries in Patients with Monocular Blindness Caused by Injection of Hyaluronic Acid in Facial Tissues".Aesthetic plastic surgery · 2021Article
- Dynamic Observation of the Effect of L-Theanine on Cerebral Ischemia-Reperfusion Injury Using Magnetic Resonance Imaging under Mathematical Model Analysis.Journal of healthcare engineering · 2021Article
- Fovea Sparing Branch Retinal Artery Occlusions Imaged with Optical Coherence Tomography Angiography: Two Case Reports.Case reports in ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCentral retinal artery occlusion is an ophthalmic emergency which typically causes acute, painless visual loss. Several conservative treatment options are practiced with little benefit. Thrombolysis as a therapeutic option has gathered interest as well as controversy. This paper aims at reviewing the relevant literature to assess the efficacy and safety of intra-arterial thrombolysis for acute central retinal artery occlusion.
methodsA review of the literature was conducted. Keywords included "intra-arterial thrombolysis" or "intra-arterial fibrinolysis" in combination with "central retinal artery occlusion" or "CRAO". A Cochrane Database search was performed for randomised control trials, systematic reviews and meta-analyses using the same keywords.
resultsTwenty-eight studies were identified which included case reports, case series, case-control studies and 1 randomised control trial: the European Assessment Group for Lysis in the Eye Study. Improvement in vision was measured using different methods and at different time points. The findings of these studies generally favour an effect towards intra-arterial thrombolysis however there are many limitations. Additionally, the European Assessment Group for Lysis in the Eye Study showed lack of effect in intra-arterial thrombolysis vs conservative measures.
conclusionCurrent evidence is not sufficient to recommend intra-arterial thrombolysis due to the variability of visual improvement within retrospective studies, heterogeneity in treatment regimens between studies and adverse effects. Intra-arterial thrombolysis may have a role in patients presenting early, particularly if they have monocular vision, after discussion of the risks and benefits. Further high-quality trials assessing the clinical efficacy of intra-arterial thrombolysis may shed more light on this topic.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.