ArticleNature2020
Metabolic heterogeneity confers differences in melanoma metastatic potential.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 354 papers.
0numbers the graph read from it
0cells of the map it votes in
354citing papers in PubMed
35.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
354 citing papers in PubMed, 496 citations in OpenAlex.
- Metabolites and cancer metastasis.Oncogene · 2026Review
- Targeting Cystine Addiction Suppresses Breast Cancer Lung Metastasis.Cancer research · 2026Article
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- A simple, anesthesia-free infusion technique for in vivo metabolic tracing.Science advances · 2026Article
- Hypoxia-inducible factor-1α promotes the malignant progression of cervical cancer cells by regulating lactate dehydrogenase A-mediated glycolysis.Translational cancer research · 2026Article
- Lysine l-Lactylation: Bridging Metabolism, Chromatin and Disease.Cell proliferation · 2026Review
- Immune-Metabolic Profiling Reveals Functional Heterogeneity Within Colorectal Cancer Consensus Molecular Subtypes.Biology · 2026Article
- Review
- Real-World Treatment Outcomes After Nivolumab Progression in BRAF-Negative Metastatic Melanoma: A Multicenter Cohort Study by the Turkish Oncology Group.Journal of clinical medicine · 2026Article
- Dissecting autonomous enzymatic variability in single cells.Nature communications · 2026Article
- Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization.Molecular metabolism · 2026Article
- Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Immune cross talk and therapeutic advances in lactate metabolism in the tumor microenvironment (Review).Experimental and therapeutic medicine · 2026Review
- A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026Review
- l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.The Journal of clinical investigation · 2026Article
- Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice.Nature metabolism · 2026Article
- Research progress in single‑cell omics technologies for kidney disease (Review).International journal of molecular medicine · 2026Review
- BPGM as an intrinsic brake to constrain metastasis through phospho-epigenetic-mediated carnitine biosynthesis suppression.Neoplasia (New York, N.Y.) · 2026Article
- DHX37 and tumor growth: a novel avenue for melanoma research.Journal of translational medicine · 2026Article
- The metabolic profiles of cancer stem cells.Stem cell research & therapy · 2026Review
294 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Alpaslan TasdoganChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Brandon FaubertChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Vijayashree RameshChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jessalyn M UbellackerChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bo ShenChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ashley SolmonsonChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Malea M MurphyChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhimin GuChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wen GuChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Misty MartinChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Stacy Y KasitinonChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Travis VandergriffDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Thomas P MathewsChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhiyu ZhaoChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dirk SchadendorfDepartment of Dermatology, University Hospital, University Duisburg-Essen, Essen and German Cancer Consortium (DKTK), Heidelberg, Germany.
Ralph J DeBerardinisChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. ralph.deberardinis@UTSouthwestern.edu.
Sean J MorrisonChildren's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. sean.morrison@UTSouthwestern.edu.
The University of Texas Southwestern Medical Center · USHeidelberg University · DEHoward Hughes Medical Institute · USSouthwestern Medical Center · US
Funding
Metabolic Regulators of Tumor Growth and ProgressionR35CA220449 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RALPH J DEBERARDINIS · 2017 to 2026
$9.4MThe Metabolic Regulation of Melanoma MetastasisU01CA228608 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MORRISON, SEAN J · 2019 to 2023
$2.9MThe consequences of human inborn errors in mitochondrial lipoic acid metabolismF32HD096786 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI SOLMONSON, ASHLEY D · 2018 to 2020
$197kCharacterization of a new growth factor from a bone marrow vascular nicheF32HL139016 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHEN, BO · 2017 to 2019
$179kHoward Hughes Medical InstituteNCI NIH HHS R35 CA220449NCI NIH HHS U01 CA228608NHLBI NIH HHS F32 HL139016NICHD NIH HHS F32 HD096786
Abstract
Metastasis requires cancer cells to undergo metabolic changes that are poorly understood
Indexed as
AnimalsCell Line, TumorCell SurvivalHumansMelanomaMiceMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersOxidative StressSymportersXenograft Model Antitumor AssaysMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersSymporters
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.