ArticleNature2020
Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.
Abstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
145 citing papers in PubMed, 1 synthesis or guideline pooled it, 249 citations in OpenAlex.
- Organoid Models of Colorectal Pathology: Do They Hold the Key to Personalized Medicine? A Systematic Review.Diseases of the colon and rectum · 2020Pooled it
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- RADX protects against intestinal inflammation by restraining IFI16-mediated innate immunity.EMBO molecular medicine · 2026Article
- Inflammatory bowel disease and cancer-driving mutations occupy different cellular neighborhoods.Nature genetics · 2026Article
- The role of cytotoxicity in the process of carcinogenesis.Archives of toxicology · 2026Article
- Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitis.Nature genetics · 2026Article
- Context-dependent selection sculpts mutational landscapes in the normal lung.Research square · 2026Article
- Pathophysiology of colitis-associated colorectal cancer.Nature reviews. Gastroenterology & hepatology · 2026Review
- Activation-induced cytidine deaminase promotes DNA demethylation and expression of the Ninjurin-2 gene.Biology open · 2026Article
- Age distinguishes selection from causation in cancer genomes.Nature genetics · 2026Article
- Exome sequencing directly implicates 68 genes in inflammatory bowel disease.medRxiv : the preprint server for health sciences · 2026Article
- RNA-binding proteins and ribonucleoproteins as determinants of immunity.Nature reviews. Immunology · 2026Review
- The Role of Regnase-1 in Autoimmune Diseases - A Future Therapeutic Target for Clinical Use.Clinical reviews in allergy & immunology · 2026Review
- Somatic mutations and clonal evolution in normal tissues and cancer development.Experimental & molecular medicine · 2026Review
- Targeting IBD treatment: smart drug delivery systems for oral administration.Materials today. Bio · 2026Review
- Colitis-Associated Carcinoma: The Quintessential Epithelial Neoplasia Driven by Chronic Inflammation.Cells · 2026Review
- Review
- Integrated Single Cell Spatial Analysis Reveals Dysregulated Basal Progenitor Cells in Ulcerative Colitis Pathogenesis: A Multi Omics Study.Health science reports · 2026Article
- The Regnase pathway: a core axis in immune regulation and inflammatory disease.Frontiers in immunology · 2026Review
- Epigenomic control of immunity: from mechanisms to therapeutic targets in inflammatory bowel diseases.International immunology · 2025Review
85 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
54 authors at 13 institutions in 2 countries.
Nobuyuki KakiuchiDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Kenichi YoshidaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Motoi UchinoDepartment of Inflammatory Bowel Disease, Division of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Takako KiharaDepartment of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Kotaro AkakiDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yoshikage InoueDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Kenji KawadaDepartment of Surgery, Kyoto University, Kyoto, Japan.
Satoshi NagayamaGastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Akira YokoyamaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Shuji YamamotoDepartment of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan.
Minoru MatsuuraDepartment of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan.
Takahiro HorimatsuDepartment of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tomonori HiranoDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Norihiro GotoDepartment of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan.
Yasuhide TakeuchiDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Yotaro OchiDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Yusuke ShiozawaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Yasunori KogureDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Yosaku WatataniDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Yoichi FujiiDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Soo Ki KimDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Ayana KonDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Keisuke KataokaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Tetsuichi YoshizatoDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Masahiro M NakagawaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Akinori YodaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Yasuhito NanyaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Hideki MakishimaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Yuichi ShiraishiLaboratory of DNA Information Analysis, Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Kenichi ChibaLaboratory of DNA Information Analysis, Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Hiroko TanakaLaboratory of Sequence Analysis, Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Masashi SanadaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Eiji SugiharaResearch and Development Centre for Precision Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Taka-Aki SatoResearch and Development Centre for Precision Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Takashi MaruyamaDepartment of Immunology, Akita University Graduate School of Medicine, Akita, Japan.
Hiroyuki MiyoshiDivision of Experimental Therapeutics, Kyoto University, Kyoto, Japan.
Makoto Mark TaketoDivision of Experimental Therapeutics, Kyoto University, Kyoto, Japan.
Jun OishiDSP Cancer Institute, Sumitomo Dainippon Pharma, Osaka, Japan.
Ryosaku InagakiDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan.
Yutaka UedaDSP Cancer Institute, Sumitomo Dainippon Pharma, Osaka, Japan.
Shinya OkamotoDivision of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hideaki OkajimaDivision of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yoshiharu SakaiDepartment of Surgery, Kyoto University, Kyoto, Japan.
Takaki SakuraiDepartment of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Hironori HagaDepartment of Diagnostic Pathology, Kyoto University, Kyoto, Japan.
Seiichi HirotaDepartment of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Hiroki IkeuchiDepartment of Inflammatory Bowel Disease, Division of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Hiroshi NakaseDepartment of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan.
Hiroyuki MarusawaDepartment of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan.
Tsutomu ChibaDepartment of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan.
Osamu TakeuchiDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Satoru MiyanoLaboratory of DNA Information Analysis, Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Hiroshi SenoDepartment of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan.
Seishi OgawaDepartment of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan. sogawa-tky@umin.ac.jp.
Kyoto University · JPHyogo Medical University · JPThe University of Tokyo · JPKyoto University Hospital · JPSumitomo Dainippon Pharma (Japan) · JPUniversity of Tsukuba · JPAkita University · JPJapanese Foundation For Cancer Research · JPKanazawa Medical University · JPKansai Electric Power Hospital · JPNagoya Medical Center · JPNational Cancer Centre Japan · JPNational Cancer Research Institute · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair and is associated with an increased risk of cancer
Indexed as
Mutation RateAdaptor Proteins, Signal TransducingAnimalsCell Line, TumorColitis, UlcerativeColorectal NeoplasmsHumansMiceSignal TransductionAdaptor Proteins, Signal TransducingNFKBIZ protein, humanNfkbiz protein, mouse
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.