ArticleScientific reports2019
Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Measurement of HbA1c with a new phase function using RBC phase image from a low-cost digital holographic microscopy.Biotechnology letters · 2025Article
- Revealing 3D microanatomical structures of unlabeled thick cancer tissues using holotomography and virtual H&E staining.Nature communications · 2025Article
- White Light Diffraction Phase Microscopy in Imaging of Breast and Colon Tissues.Diagnostics (Basel, Switzerland) · 2024Article
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- Recent Advances and Current Trends in Transmission Tomographic Diffraction Microscopy.Sensors (Basel, Switzerland) · 2024Review
- Microindentation of fresh soft biological tissue: A rapid tissue sectioning and mounting protocol.PloS one · 2024Article
- Artificial intelligence-enabled quantitative phase imaging methods for life sciences.Nature methods · 2023Review
- Quantitative Phase Imaging Using Digital Holographic Microscopy to Assess the Degree of Intestinal Inflammation in Patients with Ulcerative Colitis.Journal of clinical medicine · 2023Article
- Quantification of structural heterogeneity in H&E stained clear cell renal cell carcinoma using refractive index tomography.Biomedical optics express · 2023Article
- Long-term label-free assessments of individual bacteria using three-dimensional quantitative phase imaging and hydrogel-based immobilization.Scientific reports · 2023Article
- Multimodal image reconstruction from tomographic diffraction microscopy data.Journal of microscopy · 2022Article
- Investigating the role of heat shock protein 47 in fibrosis in Crohn's disease.Scientific reports · 2022Article
- Observational
- Article
- Indentation probe with optical fibre array-based optical coherence tomography for material deformation.Journal of microscopy · 2021Article
- Assessment of nanoindentation in stiffness measurement of soft biomaterials: kidney, liver, spleen and uterus.Scientific reports · 2020Article
- Smart filtering of phase residues in noisy wrapped holograms.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Intestinal strictures are a frequent complication in patients with Crohn's Disease (CD) and the presence of fibrosis within strictures impacts the therapeutic treatment approach. Here, we evaluate quantitative phase imaging (QPI) using digital holographic microscopy (DHM) for the evaluation of fibrosis within CD strictures. 30 full thickness resection specimens were obtained from non-stenotic and stenotic tissue areas of 15 CD patients. Cryostat sections were analyzed by DHM to measure the spatial distribution of the refractive index (RI) to quantify tissue density. Complementary, histopathological evaluation of H&E staining and immunofluorescence (IF) targeting fibrosis markers served as the gold standard. Moreover, tissue stiffness was evaluated by elastography. RI values assessed by DHM were significantly higher in stenotic compared to non-stenotic tissue areas (p < 0.001). Histopathological analysis using H&E staining and IF confirmed the elevated expression of fibrosis markers in stenotic compared to non-stenotic tissue (all p < 0.001). The RI retrieved by DHM strongly correlated with the amount of fibrosis as determined by IF (p < 0.001; R
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