Evidence map›Paper›PMID 31852978›Full record

ArticleScientific reports2019

Triple-marker cardiac MRI detects sequential tissue changes of healing myocardium after a hydrogel-based therapy.

Maaike van den Boomen, Hanne B Kause, Hans C van Assen, Patricia Y W Dankers, Carlijn V C Bouten, Katrien Vandoorne

Erratum issuedAbstract read
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In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Maaike van den BoomenDepartment of Biomedical Engineering, Cell-Matrix Interaction for Cardiovascular Tissue Regeneration, Eindhoven University of Technology, Eindhoven, The Netherlands.ORCID http://orcid.org/0000-0003-2526-6553
Hanne B KauseDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Hans C van AssenDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Patricia Y W DankersInstitute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands.
Carlijn V C BoutenDepartment of Biomedical Engineering, Cell-Matrix Interaction for Cardiovascular Tissue Regeneration, Eindhoven University of Technology, Eindhoven, The Netherlands.
Katrien VandoorneDepartment of Biomedical Engineering, Cell-Matrix Interaction for Cardiovascular Tissue Regeneration, Eindhoven University of Technology, Eindhoven, The Netherlands. k.vandoorne@tue.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regenerative therapies based on injectable biomaterials, hold an unparalleled potential for treating myocardial ischemia. Yet, noninvasive evaluation of their efficacy has been lagging behind. Here, we report the development and longitudinal application of multiparametric cardiac magnetic resonance imaging (MRI) to evaluate a hydrogel-based cardiac regenerative therapy. A pH-switchable hydrogel was loaded with slow releasing insulin growth factor 1 and vascular endothelial growth factor, followed by intramyocardial injection in a mouse model of ischemia reperfusion injury. Longitudinal cardiac MRI assessed three hallmarks of cardiac regeneration: angiogenesis, resolution of fibrosis and (re)muscularization after infarction. The multiparametric approach contained dynamic contrast enhanced MRI that measured improved vessel features by assessing fractional blood volume and permeability*surface area product, T

Indexed as

AnimalsBiocompatible MaterialsDisease Models, AnimalHeartHumansHydrogelsHydrogen-Ion ConcentrationInsulin-Like Growth Factor IMiceMyocardial IschemiaMyocardiumNeovascularization, PhysiologicRegenerative MedicineVascular Endothelial Growth Factor ABiocompatible MaterialsHydrogelsinsulin-like growth factor-1, mouseInsulin-Like Growth Factor IVascular Endothelial Growth Factor A

Identifiers

PMID31852978
PMCPMC6920418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.