ArticleNature communications2019
CD8
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
14.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Clinical Characterization and Ancillary Tests in Susac Syndrome: A Systematic Review.Neurology(R) neuroimmunology & neuroinflammation · 2024Pooled it
- Endothelial Cell Proteins as Biomarkers in Susac Syndrome.Annals of clinical and translational neurology · 2026Article
- Autoimmune Diseases and the Vestibular and Oculomotor System: Clinical Presentation, Diagnosis, and Treatment.Journal of eye movement research · 2026Review
- Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA.Nature communications · 2026Article
- Evolution of Susac syndrome with a long interval between the attacks: a diagnostic challenge.Journal of neurology · 2026Article
- Immune-mediated cochleovestibular dysfunction: clinical spectrum from isolated inner-ear disorders to systemic autoimmune diseases and therapeutic strategies.Frontiers in immunology · 2026Review
- Mechanisms and therapeutic advances of gut metabolites in the regulation of neuroimmune inflammatory diseases.Frontiers in immunology · 2026Review
- Cytotoxic T lymphocytes and their dual role in modulating blood-brain barrier integrity in immune-mediated neurological pathologies.Journal of translational medicine · 2025Review
- Neuron-reactive KIRNature communications · 2025Article
- Incomplete Susac Syndrome With Recurrent Retinal Occlusions and Vertigo: A Case of Early Immunosuppressive Success.Cureus · 2025Article
- Restoring brain barriers: an innovative approach for treating neurological disorders.Fluids and barriers of the CNS · 2025Review
- CD8 T cells as drivers of blood-brain barrier disruption.Trends in neurosciences · 2025Review
- Gut-immune-brain interactions during neurodevelopment: from a brain-centric to a multisystem perspective.BMC medicine · 2025Review
- Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation.Brain : a journal of neurology · 2025Article
- Successful Natalizumab Treatment of Two Female Individuals With Susac Syndrome.European journal of neurology · 2025Article
- Phenotyping vestibulocochlear manifestations in Susac syndrome: a cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Clinical Characterization and Prognostic Risk Factors of Susac Syndrome: A Retrospective Multicenter Study.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Brain microstructural damage through serial diffusion tensor imaging and outcomes in Susac syndrome: A prospective cohort study.European journal of neurology · 2025Article
- Susac syndrome: A rare pediatric case.Radiology case reports · 2024Article
- Risk factors for severe hearing loss in Susac syndrome: A national cohort study.European journal of neurology · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 15 institutions in 6 countries.
Catharina C GrossDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. Catharina.Gross@ukmuenster.de.ORCID http://orcid.org/0000-0002-4872-9189
Céline MeyerCentre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, CHU Purpan - BP 3028 - 31024, Toulouse Cedex 3, Toulouse, France.
Urvashi BhatiaDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0003-4923-4492
Lidia YshiiCentre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, CHU Purpan - BP 3028 - 31024, Toulouse Cedex 3, Toulouse, France.
Ilka KleffnerDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0003-3207-9684
Jan BauerDepartment of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0001-5802-8047
Anna R TröscherDepartment of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0003-3003-4677
Andreas Schulte-MecklenbeckDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0003-3855-4706
Sebastian HerichDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0001-8976-7811
Tilman Schneider-HohendorfDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0002-3717-5176
Henrike PlateDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0003-3343-6874
Tanja KuhlmannInstitute of Neuropathology, University Hospital Münster, University of Münster, Pottkamp 2, 48149, Münster, Germany.ORCID http://orcid.org/0000-0002-0174-5042
Markus SchwaningerInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Wolfgang BrückInstitute of Neuropathology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37099, Göttingen, Germany.ORCID http://orcid.org/0000-0002-6881-4479
Marc PawlitzkiDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0003-3080-2277
David-Axel LaplaudUMR 1064, INSERM, Centre de Recherche en Transplantation et Immunologie, Université de Nantes, CHU Nantes - Hôtel Dieu Bd Jean Monnet, 44093, Nantes Cedex 01, France.ORCID http://orcid.org/0000-0001-6113-6938
Delphine LoussouarnService d'Anatomo-Pathologie, CHU Nantes, Hôtel-Dieu, rez-de-jardin, 44093, Nantes Cedex 1, France.
John ParrattDepartment of Neurology, Royal North Shore Hospital, Sydney, Australia.
Michael BarnettBrain and Mind Centre, Medical Faculty, University of Sydney, Mallett Street, Camperdown, Sydney, NSW, 2050, Australia.
Michael E BucklandBrain and Mind Centre, Medical Faculty, University of Sydney, Mallett Street, Camperdown, Sydney, NSW, 2050, Australia.ORCID http://orcid.org/0000-0003-4755-6471
Todd A HardyBrain and Mind Centre, Medical Faculty, University of Sydney, Mallett Street, Camperdown, Sydney, NSW, 2050, Australia.
Stephen W ReddelBrain and Mind Centre, Medical Faculty, University of Sydney, Mallett Street, Camperdown, Sydney, NSW, 2050, Australia.
Marius RingelsteinDepartment of Neurology, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225, Düsseldorf, Germany.ORCID http://orcid.org/0000-0003-3618-8407
Jan DörrMax Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure, Experimental and Clinical Research Center, Charitéplatz 1, 10117, Berlin, Germany.
Brigitte WildemannMolecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Markus KraemerDepartment of Neurology, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-5667-3621
Hans LassmannDepartment of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0001-8617-5052
Romana HöftbergerInstitute of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Eduardo BeltránInstitute of Clinical Neuroimmunology, Biomedical Center and Hospital of the Ludwig-Maximilians-University Munich, Großhaderner Straße 9, Martinsried, 82152, Munich, Germany.ORCID http://orcid.org/0000-0002-7266-4098
Klaus DornmairInstitute of Clinical Neuroimmunology, Biomedical Center and Hospital of the Ludwig-Maximilians-University Munich, Großhaderner Straße 9, Martinsried, 82152, Munich, Germany.ORCID http://orcid.org/0000-0003-0342-5373
Nicholas SchwabDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0001-5494-9885
Luisa KlotzDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0001-5439-9633
Sven G MeuthDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.ORCID http://orcid.org/0000-0003-2571-3501
Guillaume Martin-BlondelCentre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, CHU Purpan - BP 3028 - 31024, Toulouse Cedex 3, Toulouse, France.
Heinz WiendlDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. Heinz.Wiendl@ukmuenster.de.
Roland LiblauCentre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, CHU Purpan - BP 3028 - 31024, Toulouse Cedex 3, Toulouse, France. Roland.Liblau@inserm.fr.ORCID http://orcid.org/0000-0001-5477-5475
University of Münster · DEThe University of Sydney · AUCentre National de la Recherche Scientifique · FRMedical University of Vienna · ATAlfried Krupp Hospital · DEBlackberry (United States) · USCentre d'Investigation Clinique de Nantes · FRHeidelberg University · DEHeinrich Heine University Düsseldorf · DEHumboldt-Universität zu Berlin · DEInserm · FRLudwig-Maximilians-Universität München · DEMunich Cluster for Systems Neurology · DEUniversitätsmedizin Göttingen · DEUniversity of Lübeck · DE
Funding
Austrian Science Fund FWF P 26936
Abstract
Neuroinflammation is often associated with blood-brain-barrier dysfunction, which contributes to neurological tissue damage. Here, we reveal the pathophysiology of Susac syndrome (SuS), an enigmatic neuroinflammatory disease with central nervous system (CNS) endotheliopathy. By investigating immune cells from the blood, cerebrospinal fluid, and CNS of SuS patients, we demonstrate oligoclonal expansion of terminally differentiated activated cytotoxic CD8
Indexed as
AdultAnimalsCell AdhesionCentral Nervous SystemDisease Models, AnimalEndothelium, VascularFemaleHumansIntegrin alpha4MaleMice, TransgenicMicrovesselsMiddle AgedNatalizumabSusac SyndromeT-Lymphocytes, CytotoxicIntegrin alpha4Natalizumab
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.