ArticleTranslational psychiatry2019
Reduced visual evoked potential amplitude in autism spectrum disorder, a variability effect?
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- The role of single trial variability in event related potentials in children with attention deficit hyperactivity disorder.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Trial
- Reduced Motor Preparation and Altered EEG Signatures of Prediction in Autistic Adults.The European journal of neuroscience · 2026Article
- Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG.Autism research : official journal of the International Society for Autism Research · 2026Article
- Visual Cortical Response Variability in Infants at High Familial Likelihood for Autism.Developmental science · 2026Article
- From heterogeneity to translation: data‑driven subtyping of autism in a multilevel framework.Translational psychiatry · 2026Review
- Variability in sensory processing and evoked potentials in Rett syndrome.medRxiv : the preprint server for health sciences · 2026Article
- Review
- Visual Cortical Response Variability in Infants at High Familial Likelihood for Autism.bioRxiv : the preprint server for biology · 2026Article
- Comparison of visual evoked potential variability in eyes affected by optic neuritis and fellow eyes.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Separating early and intermediate vision EEG signatures of facial emotion recognition in a fast divided attention task to eye and mouth features.Frontiers in cognition · 2026Article
- Unraveling variability in young children's brain responses to varied sensory stimulations.iScience · 2025Article
- Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome.Journal of neurodevelopmental disorders · 2025Article
- The maturation of infant and toddler visual cortex neural activity and associations with fine motor performance.Developmental cognitive neuroscience · 2025Article
- Parsing evoked and induced gamma response differences in Autism: A visual evoked potential study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Article
- Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome.Journal of neurodevelopmental disorders · 2024Article
- "Neural Noise" in Auditory Responses in Young Autistic and Neurotypical Children.Journal of autism and developmental disorders · 2024Article
- Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1Nature communications · 2023Article
- The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers.The American journal of psychiatry · 2023Article
- Evidence towards a continuum of impairment across neurodevelopmental disorders from basic ocular-motor tasks.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical sensory behaviours represent a core symptom of autism spectrum disorder (ASD). Investigating early visual processing is crucial to deepen our understanding of higher-level processes. Visual evoked potentials (VEPs) to pattern-reversal checkerboards were recorded in ASD children and age-matched controls. Peak analysis of the P100 component and two types of single-trial analyses were carried out. P100 amplitude was reduced in the ASD group, consistent with previous reports. The analysis of the proportion of trials with a positive activity in the latency range of the P100, measuring inter-trial (in)consistency, allowed identifying two subgroups of ASD participants: the first group, as control children, showed a high inter-trial consistency, whereas the other group showed an inter-trial inconsistency. Analysis of median absolute deviation of single-trial P100 (st-P100) latencies revealed an increased latency variability in the ASD group. Both single-trial analyses revealed increased variability in a subset of children with ASD. To control for this variability, VEPs were reconstructed by including only positive trials or trials with homogeneous st-P100 latencies. These control analyses abolished group differences, confirming that the reduced P100 amplitude results from increased inter-trial variability in ASD. This increased variability in ASD supports the neural noise theory. The existence of subgroups in ASD suggests that the neural response variability is not a genuine characteristic of the entire autistic spectrum, but rather characterized subgroups of children. Exploring the relationship between sensory responsiveness and inter-trial variability could provide more precise bioclinical profiles in children with ASD, and complete the functional diagnostic crucial for the development of individualized therapeutical projects.
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