ArticleTranslational psychiatry2019
Longitudinal transcriptome-wide gene expression analysis of sleep deprivation treatment shows involvement of circadian genes and immune pathways.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder.Translational psychiatry · 2023Trial
- Circadian rhythms in major depressive disorder: mechanistic insights and therapeutic frontiers.Annals of medicine · 2026Review
- Acute Sleep Deprivation and the Autoimmune TLR-BANK1 Pathway: Interplay with Gender and Emotional State.International journal of molecular sciences · 2025Article
- Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner.Translational psychiatry · 2025Article
- Circadian Rhythm Genes and Their Association with Sleep and Sleep Restriction.International journal of molecular sciences · 2024Article
- Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation.Sleep & breathing = Schlaf & Atmung · 2024Article
- Higher Seasonal Variation of Systemic Inflammation in Bipolar Disorder.International journal of molecular sciences · 2024Article
- Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism.iScience · 2024Article
- Urolithin A Prevents Sleep-deprivation-induced Neuroinflammation and Mitochondrial Dysfunction in Young and Aged Mice.Molecular neurobiology · 2024Article
- ISLET: individual-specific reference panel recovery improves cell-type-specific inference.Genome biology · 2023Observational
- The multiple roles of salt-inducible kinases in regulating physiology.Physiological reviews · 2023Review
- Temporal effects on death by suicide: empirical evidence and possible molecular correlates.Discover mental health · 2023Article
- Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection.iScience · 2023Article
- Rapid-acting antidepressants and the circadian clock.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- The contribution of sleep to the neuroendocrine regulation of rhythms in human leukocyte traffic.Seminars in immunopathology · 2022Review
- Per1 gene polymorphisms influence the relationship between brain white matter microstructure and depression risk.Frontiers in psychiatry · 2022Article
- Ischemic Stroke and Sleep: The Linking Genetic Factors.Cardiology and therapy · 2021Review
- Effective Antidepressant Chronotherapeutics (Sleep Deprivation and Light Therapy) Normalize the IL-1β:IL-1ra Ratio in Bipolar Depression.Frontiers in physiology · 2021Article
- Single cell profiling of capillary blood enables out of clinic human immunity studies.Scientific reports · 2020Article
- Immunological pathways of macrophage response toInnate immunity · 2020Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic sleep deprivation (SD) rapidly induces robust, transient antidepressant effects in a large proportion of major mood disorder patients suffering from a depressive episode, but underlying biological factors remain poorly understood. Research suggests that these patients may have altered circadian molecular genetic 'clocks' and that SD functions through 'resetting' dysregulated genes; additional factors may be involved, warranting further investigation. Leveraging advances in microarray technology enabling the transcriptome-wide assessment of gene expression, this study aimed to examine gene expression changes accompanying SD and recovery sleep in patients suffering from an episode of depression. Patients (N = 78) and controls (N = 15) underwent SD, with blood taken at the same time of day before SD, after one night of SD and after recovery sleep. A transcriptome-wide gene-by-gene approach was used, with a targeted look also taken at circadian genes. Furthermore, gene set enrichment, and longitudinal gene set analyses including the time point after recovery sleep, were conducted. Circadian genes were significantly affected by SD, with patterns suggesting that molecular clocks of responders and non-responders, as well as patients and controls respond differently to chronobiologic stimuli. Notably, gene set analyses revealed a strong widespread effect of SD on pathways involved in immune function and inflammatory response, such as those involved in cytokine and especially in interleukin signalling. Longitudinal gene set analyses showed that in responders these pathways were upregulated after SD; in non-responders, little response was observed. Our findings emphasize the close relationship between circadian, immune and sleep systems and their link to etiology of depression at the transcriptomic level.
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