ArticleProceedings of the National Academy of Sciences of the United States of America2020
Photoreversible interconversion of a phytochrome photosensory module in the crystalline state.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 28 citations in OpenAlex.
- Computational Protocols to Study Phytochromes.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Sample delivery methods for protein X-ray crystallography with a special focus on sample consumption.Nature communications · 2025Review
- Serial-femtosecond crystallography reveals how a phytochrome variant couples chromophore and protein structural changes.Science advances · 2025Article
- Structures of myxobacterial phytochrome revealed by cryo-EM using the Spotiton technique and with x-ray crystallography.Structural dynamics (Melville, N.Y.) · 2025Article
- Endocrine control of gill ionocyte function in euryhaline fishes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Signaling by a bacterial phytochrome histidine kinase involves a conformational cascade reorganizing the dimeric photoreceptor.Nature communications · 2024Article
- Crystal structure of the photosensory module from a PAS-less cyanobacterial phytochrome as Pr shows a mix of dark-adapted and photoactivated features.The Journal of biological chemistry · 2024Article
- Green/red light-sensing mechanism in the chromatic acclimation photosensor.Science advances · 2024Article
- The structure of Arabidopsis phytochrome A reveals topological and functional diversification among the plant photoreceptor isoforms.Nature plants · 2023Article
- The molecular mechanism of light-induced bond formation and breakage in the cyanobacteriochrome TePixJ.Physical chemistry chemical physics : PCCP · 2023Article
- Article
- Article
- Bistable Photoswitch Allows in Vivo Control of Hematopoiesis.ACS central science · 2022Article
- The Red Edge: Bilin-Binding Photoreceptors as Optogenetic Tools and Fluorescence Reporters.Chemical reviews · 2021Review
- Radiation damage to biological samples: still a pertinent issue.Journal of synchrotron radiation · 2021Article
- An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography.Nature communications · 2021Article
- Pump-Probe Circular Dichroism Spectroscopy of Cyanobacteriochrome TePixJ Yields: Insights into Its Photoconversion.The journal of physical chemistry. B · 2021Article
- Dynamic Structural Biology Experiments at XFEL or Synchrotron Sources.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Photocycle of Cyanobacteriochrome TePixJ.Biochemistry · 2020Article
- Spectral and photochemical diversity of tandem cysteine cyanobacterial phytochromes.The Journal of biological chemistry · 2020Article
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Authors and funding
27 authors at 6 institutions in 2 countries.
E Sethe BurgieDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130.ORCID 0000-0002-6520-9126
Jonathan A ClingerDepartment of Biosciences, Rice University, Houston, TX 77005.
Mitchell D MillerDepartment of Biosciences, Rice University, Houston, TX 77005.
Aaron S BrewsterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Pierre AllerDiamond Light Source Ltd., Didcot, Oxfordshire OX11 0DE, United Kingdom.
Agata ButrynDiamond Light Source Ltd., Didcot, Oxfordshire OX11 0DE, United Kingdom.
Franklin D FullerLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025.
Sheraz GulMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Iris D YoungMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Cindy C PhamMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
In-Sik KimMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Asmit BhowmickMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Lee J O'RiordanMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Kyle D SutherlinMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Joshua V HeinemannMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Alexander BatyukLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025.ORCID 0000-0002-9393-2880
Roberto Alonso-MoriLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025.
Mark S HunterLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025.
Jason E KoglinLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025.
Junko YanoMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Vittal K YachandraMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Nicholas K SauterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Aina E CohenStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA 94025.
Jan KernMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; jfkern@lbl.gov allen.orville@diamond.ac.uk georgep@rice.edu rdvierstra@wustl.edu.ORCID 0000-0002-7272-1603
Allen M OrvilleDiamond Light Source Ltd., Didcot, Oxfordshire OX11 0DE, United Kingdom; jfkern@lbl.gov allen.orville@diamond.ac.uk georgep@rice.edu rdvierstra@wustl.edu.ORCID 0000-0002-7803-1777
George N PhillipsDepartment of Biosciences, Rice University, Houston, TX 77005; jfkern@lbl.gov allen.orville@diamond.ac.uk georgep@rice.edu rdvierstra@wustl.edu.
Richard D VierstraDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130; jfkern@lbl.gov allen.orville@diamond.ac.uk georgep@rice.edu rdvierstra@wustl.edu.ORCID 0000-0003-0210-3516
Lawrence Berkeley National Laboratory · USSLAC National Accelerator Laboratory · USRice University · USDiamond Light Source · GBWashington University in St. Louis · USRutherford Appleton Laboratory · GB
Funding
X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6MTaking Snapshots of the Water-Oxidation Reaction by the Mn4Ca Oxygen-Evolving Complex Using X-ray Crystallography and SpectroscopyR01GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 1997 to 2022
$9.1MDIALS: New Computational Methods to Enable Challenging Crystallographic ExperimentsR01GM117126 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SAUTER, NICHOLAS K · 2016 to 2023
$6.1MBiological Spectroscopy and Crystallography Using an X-ray Free Electron Laser - Supplemental EquipmentR01GM110501 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Junko Yano · 2014 to 2026
$4.8MHigh throughput sample delivery method for time resolved studies of enzyme reactions with X-ray and complementary techniquesR01GM126289 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KERN, JAN F · 2017 to 2025
$4.6MPhytochromes: Structural Perspectives on Photoactivation and SignalingR01GM127892 · NIGMS · WASHINGTON UNIVERSITY · PI JEZ, JOSEPH MARTIN · 2018 to 2025
$2.5MHigh-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0MStructure and Function of the Mn Oxygen-Evolving ComplexR56GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 2009 to 2009
$530kBiotechnology and Biological Sciences Research CouncilNIGMS NIH HHS P41 GM103393NIGMS NIH HHS R01 GM055302NIGMS NIH HHS R01 GM110501NIGMS NIH HHS R01 GM117126NIGMS NIH HHS R01 GM126289NIGMS NIH HHS R01 GM127892NIGMS NIH HHS R56 GM055302NIH HHS S10 OD012289Wellcome TrustWellcome Trust 102593Wellcome Trust 210734/Z/18/Z
Abstract
A major barrier to defining the structural intermediates that arise during the reversible photointerconversion of phytochromes between their biologically inactive and active states has been the lack of crystals that faithfully undergo this transition within the crystal lattice. Here, we describe a crystalline form of the cyclic GMP phosphodiesterases/adenylyl cyclase/FhlA (GAF) domain from the cyanobacteriochrome PixJ in
Indexed as
Adenylyl CyclasesCrystallographyCrystallography, X-RayCyanobacteriaCyclic GMPLightModels, MolecularPhosphoric Diester HydrolasesPhotoreceptor CellsPhycobilinsPhycocyaninPhytochromeProtein ConformationProtein DomainsThermosynechococcusTrans-ActivatorsAdenylyl CyclasesCyclic GMPPhosphoric Diester HydrolasesPhycobilinsPhycocyaninphycocyanobilinphycoviolobilinPhytochromeTrans-ActivatorsphotoreceptorphytochromeX-ray crystallography
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