Evidence map›Paper›PMID 31852821›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity.

Chiwei Xu, Brian Franklin, Hong-Wen Tang, Yannik Regimbald-Dumas, Yanhui Hu, Justine Ramos, Justin A Bosch, Christians Villalta, Xi He, Norbert Perrimon

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Intestinal Stem Cells: Regulation, Plasticity, and Therapeutic Potential.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
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  9. Delineating Purinergic Signaling inInternational journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chiwei XuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Brian FranklinDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Hong-Wen TangDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Yannik Regimbald-DumasF. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Justine RamosDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Justin A BoschDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Christians VillaltaDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Xi HeF. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115; perrimon@genetics.med.harvard.edu.
Harvard University · USBoston VA Research Institute · USHoward Hughes Medical Institute · US

Funding

Wnt Signaling in intestinal stem cells, homeostasis, and cancerR01DK121945 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI HE, XI · 2019 to 2022
$2.2M
Howard Hughes Medical InstituteNIDDK NIH HHS R01 DK121945
6 · The paper itself

Abstract

Metabolites are increasingly appreciated for their roles as signaling molecules. To dissect the roles of metabolites, it is essential to understand their signaling pathways and their enzymatic regulations. From an RNA interference (RNAi) screen for regulators of intestinal stem cell (ISC) activity in the

Indexed as

AdenosineAdenosine DeaminaseAnimalsAnimals, Genetically ModifiedCell DifferentiationCell ProliferationDown-RegulationDrosophilaDrosophila ProteinsEnterocytesGene Knockdown TechniquesGene Knock-In TechniquesMAP Kinase Signaling SystemMultipotent Stem CellsReceptors, Purinergic P1RNA InterferenceAdenosineAdenosine Deaminaseadenosine deaminase-related growth factor, DrosophilaDrosophila ProteinsReceptors, Purinergic P1adenosine deaminaseadenosine receptorintestinal stem cellRNAi screen

Identifiers

PMID31852821
PMCPMC6955304
OpenAlexW2996005914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.