Evidence map›Paper›PMID 31852807›Full record

ArticlemSphere2019

Nanoemulsion as an Effective Treatment against Human-Pathogenic Fungi.

Alexis Garcia, Yong Yi Fan, Sandeep Vellanki, Eun Young Huh, DiFernando Vanegas, Su He Wang, Soo Chan Lee

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Mucormycosis and COVID-19 pandemic: Clinical and diagnostic approach.Journal of infection and public health · 2022
    Review
  11. Frontiers in microbiology · 2022
    Article
  12. Review
  13. Nano-engineered tools in the diagnosis, therapeutics, prevention, and mitigation of SARS-CoV-2.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alexis GarciaSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Yong Yi FanMichigan Nanotechnology Institute for Medicine & Biological Sciences, University of Michigan, Ann Arbor, Michigan, USA.
Sandeep VellankiSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Eun Young HuhSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
DiFernando VanegasSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA.
Su He WangMichigan Nanotechnology Institute for Medicine & Biological Sciences, University of Michigan, Ann Arbor, Michigan, USA shidasui@umich.edu soochan.lee@utsa.edu.
Soo Chan LeeSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA shidasui@umich.edu soochan.lee@utsa.edu.
Texas Center for Infectious Disease · USUniversity of Michigan–Ann Arbor · US

Funding

UTSA RISE Research Training ProgramR25GM060655 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J · 2000 to 2022
$21.6M
NIGMS NIH HHS R25 GM060655
6 · The paper itself

Abstract

Infections triggered by pathogenic fungi cause a serious threat to the public health care system. In particular, an increase of antifungal drug-resistant fungi has resulted in difficulty in treatment. A limited variety of antifungal drugs available to treat patients has left us in a situation where we need to develop new therapeutic approaches that are less prone to development of resistance by pathogenic fungi. In this study, we demonstrate the efficacy of the nanoemulsion NB-201, which utilizes the surfactant benzalkonium chloride, against human-pathogenic fungi. We found that NB-201 exhibited

Indexed as

AnimalsAntifungal AgentsBenzalkonium CompoundsCandidiasisDisease Models, AnimalDrug CombinationsFungiMiceMicrobial Sensitivity TestsPolysorbatesSoybean OilTreatment OutcomeAntifungal AgentsBenzalkonium CompoundsDrug CombinationsNB-201 nanoemulsionPolysorbatesSoybean OilAspergillusCandida albicansCryptococcusfungal infectionMucoralesnanoemulsion

Identifiers

PMID31852807
PMCPMC6920514
OpenAlexW2995300689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.