ArticleJournal of clinical microbiology2020
Impact of a Rapid Blood Culture Diagnostic Test in a Children's Hospital Depends on Gram-Positive versus Gram-Negative Organism and Day versus Night Shift.
Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Comparison of pathogen and resistance profiles in bloodstream infections using conventional methods and multiplex RT-PCR.Molecular biology reports · 2026Article
- Artificial Intelligence model to predict resistances in Gram-negative bloodstream infections.NPJ digital medicine · 2025Article
- Metagenomic signatures of extraintestinal bacterial infection in the febrile term infant gut microbiome.Microbiome · 2025Article
- Clinical and implementation outcomes of an antimicrobial stewardship intervention for rapid blood culture diagnostics.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Opportunities for collaboration: the synergy between antimicrobial and diagnostic stewardship in pediatrics.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Review
- Evaluating the impact of rapid antimicrobial susceptibility testing for bloodstream infections: a review of actionability, antibiotic use and patient outcome metrics.The Journal of antimicrobial chemotherapy · 2024Review
- Rapid Direct Identification of Microbial Pathogens and Antimicrobial Resistance Genes in Positive Blood Cultures Using a Fully Automated Multiplex PCR Assay.Journal of Korean medical science · 2024Article
- Evaluation of a sterile, filter-based, in-house method for rapid direct bacterial identification and antimicrobial susceptibility testing using positive blood culture.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Using a Knowledge-Based Clinical Decision Support System to Reduce the Time to Appropriate Antimicrobial Therapy in Hospitalized Patients With Bloodstream Infections: A Single-Center Observational Study.Open forum infectious diseases · 2022Article
- Performance and Impact on Initial Antibiotic Choice of Direct Identification of Pathogens from Pediatric Blood Culture Bottles Using an In-House MALDI-TOF MS Protocol.Microbiology spectrum · 2021Article
- Predictive Value of Direct Disk Diffusion Testing from Positive Blood Cultures in a Children's Hospital and Its Utility in Antimicrobial Stewardship.Journal of clinical microbiology · 2021Article
- Rapid Antimicrobial Susceptibility Testing Methods for Blood Cultures and Their Clinical Impact.Frontiers in medicine · 2021Review
- New Microbiological Techniques for the Diagnosis of Bacterial Infections and Sepsis in ICU Including Point of Care.Current infectious disease reports · 2021Review
- Modern Blood Culture: Management Decisions and Method Options.Clinics in laboratory medicine · 2020Review
- Panels and Syndromic Testing in Clinical Microbiology.Clinics in laboratory medicine · 2020Review
- Use of Rapid Diagnostics To Manage Pediatric Bloodstream Infections? You Bet Your ASP!Journal of clinical microbiology · 2020Article
- Educational Case:Academic pathologyArticle
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5 authors at 2 institutions in 1 country.
Funding
Abstract
Rapid diagnostic tests (RDTs) for bloodstream infections (BSIs) decrease the time to organism identification and resistance detection. RDTs are associated with early deescalation of therapy for Gram-positive BSIs. However, it is less clear how RDTs influence antibiotic management for Gram-negative BSIs and whether RDT results are acted on during off-hours. We performed a single-center, retrospective review of children with BSI and Verigene (VG) testing at a children's hospital. Of the 301 positive cultures included in the study (196 Gram-positive, 44 Gram-negative, 32 polymicrobial, and 29 non-VG targets), the VG result had potential to impact antibiotic selection in 171 cases; among these, antibiotic changes occurred in 119 (70%) cases. For Gram-negative cultures, the Verigene result correlated with unnecessary antibiotic escalation and exposure to broader-spectrum antibiotics than needed. In contrast, for Gram-positive cultures, the VG results correlated with appropriate antibiotic selection. VG results permitted early deescalation for methicillin-susceptible
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.