Evidence map›Paper›PMID 31852741›Full record

ArticleGlobal health, science and practice2019

Effects of a Peer-Led Intervention on HIV Care Continuum Outcomes Among Contacts of Children, Adolescents, and Young Adults Living With HIV in Zimbabwe.

Talent Tapera, Nicola Willis, Kudakwashe Madzeke, Tanyaradzwa Napei, Mather Mawodzeke, Stanley Chamoko, Abigail Mutsinze, Teddy Zvirawa, Beatrice Dupwa, Aveneni Mangombe and 7 more

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Global health, science and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05516602 (Improving HIV Prevention Among Adolescent Girls and Young Women), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05516602 nacompletednot on this mapstarted 2023, after this paper: background citation

Improving HIV Prevention Among Adolescent Girls and Young Women (AGYW) in Uganda

TypeinterventionalSponsorMRC/UVRI and LSHTM Uganda Research UnitRan2023 to 2024Enrolled394ConditionsHIV-1-infectionArmsPeer Support
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 6 countries.

Talent TaperaAfricaid Zvandiri, Harare, Zimbabwe. talent.tapera@gmail.com.
Nicola WillisAfricaid Zvandiri, Harare, Zimbabwe.
Kudakwashe MadzekeAfricaid Zvandiri, Harare, Zimbabwe.
Tanyaradzwa NapeiAfricaid Zvandiri, Harare, Zimbabwe.
Mather MawodzekeAfricaid Zvandiri, Harare, Zimbabwe.
Stanley ChamokoAfricaid Zvandiri, Harare, Zimbabwe.
Abigail MutsinzeAfricaid Zvandiri, Harare, Zimbabwe.
Teddy ZvirawaAfricaid Zvandiri, Harare, Zimbabwe.
Beatrice DupwaMinistry of Health and Child Care, Harare, Zimbabwe.
Aveneni MangombeMinistry of Health and Child Care, Harare, Zimbabwe.
Anesu ChimwazaMinistry of Health and Child Care, Harare, Zimbabwe.
Talent M MakoniMinistry of Health and Child Care, Harare, Zimbabwe.
Winnie MandewoElizabeth Glaser Pediatric AIDS Foundation, Harare, Zimbabwe.
Mbazi SenkoroNational Institute for Medical Research, Muhimbili Centre, Dar es Salaam, Tanzania.
Philip OwitiInternational Union Against Tuberculosis and Lung Disease, Paris, France.
Jaya Prasad TripathyInternational Union Against Tuberculosis and Lung Disease, Paris, France.
Ajay M V KumarInternational Union Against Tuberculosis and Lung Disease, Paris, France.
Ministry of Health and Child Welfare · ZWAll India Institute of Medical Sciences, NagpurInternational Union Against Tuberculosis and Lung Disease · USNational Center for Tuberculosis and Lung Disease · GENational Institute for Medical Research · TZ

Funding

PEPFAR
6 · The paper itself

Abstract

backgroundAfricaid Zvandiri, in partnership with the Ministry of Health and Child Care (MOHCC) in Zimbabwe, implemented a comprehensive, peer-led program, focused on children, adolescents, and young adults living with HIV aged 0-24 years. The peers, known as community adolescent treatment supporters (CATS), are people living with HIV (PLHIV) aged 18-24 years who are trained and mentored to support their peers throughout the HIV care continuum through support groups, home visits, phone call reminders, and messages. We report the HIV care continuum outcomes (HIV testing uptake, antiretroviral therapy [ART] uptake, retention, and viral suppression) in a cohort of household contacts and sexual partners (aged younger than 25 years) of index children, adolescents, and young adults living with HIV identified by CATS from October 2017 to September 2018 in 24 districts of Zimbabwe.

methodsThis was a retrospective cohort study involving analysis of routine program data, extracted from electronic databases consisting of data on contacts of index PLHIV and ART outcomes. We used April 30, 2019, as the censor date for all analyses.

resultsA total of 15,223 household contacts and sexual partners with unknown HIV status (linked to 9,353 index PLHIV) were identified and referred for HIV testing. Of these, 12,114 (79.6%) were tested and 1,193 (9.8%) were HIV-positive. Of the latter, 1,153 (96.6%) were initiated on ART with 99% starting on the day of diagnosis. Of those on ART, 1,151 (99.8%) were alive on ART at 6 months and 2 (0.2%) died. A total of 1,044 (91%) children, adolescents, and young people living with HIV underwent viral load testing at 6 months or later, of whom 1,037 (99.3%) were virally suppressed (<1000 copies/ml).

conclusionThese findings add to the global evidence demonstrating the effectiveness of peer-led interventions in children, adolescents, and young adults living with HIV and justify the decision of the MOHCC in Zimbabwe to scale-up the model nationally. Future research should aim to understand the reasons for the gaps in HIV testing and viral load testing using qualitative research.

Indexed as

Peer GroupAdolescentAnti-HIV AgentsAnti-Retroviral AgentsChildCommunity Health ServicesContinuity of Patient CareFemaleHIV InfectionsHumansMaleRetrospective StudiesYoung AdultZimbabweAnti-HIV AgentsAnti-Retroviral Agents

Identifiers

PMID31852741
PMCPMC6927836
OpenAlexW2995884088

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.