Evidence map›Paper›PMID 31852732›Full record

SynthesisThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Task-Free Functional Language Networks: Reproducibility and Clinical Application.

Giovanni Battistella, Valentina Borghesani, Maya Henry, Wendy Shwe, Michael Lauricella, Zachary Miller, Jessica Deleon, Bruce L Miller, Nina Dronkers, Simona M Brambati and 3 more

Open access · bronzeAbstract readMeta-Analysis
In one paragraph

Synthesis in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  20. The Rapid Naming Test: Neuroanatomical validity and clinical utility.Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Giovanni BattistellaMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158, Giovanni.battistella@ucsf.edu.
Valentina BorghesaniMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.
Maya HenryMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.
Wendy ShweMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.
Michael LauricellaMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.
Zachary MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.ORCID 0000-0002-5991-3053
Jessica DeleonMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.ORCID 0000-0002-2152-4220
Nina DronkersDepartment of Psychology, University of California, Berkeley, California 94720, and.
Simona M BrambatiDépartement de Psychologie, Université de Montréal, Quebec H3T 1J4, Canada.
William W SeeleyMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.ORCID 0000-0003-1410-2027
Maria Luisa MandelliMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.
Maria Luisa Gorno-TempiniMemory and Aging Center, Department of Neurology, University of California, San Francisco, California 94158.
University of California, San Francisco · USUniversité de Montréal · CAUniversity of California, Berkeley · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
Connectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR01DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2017 to 2021
$3.3M
Neural Mechanisms of Language Production Decline in Primary Progressive AphasiaR01DC016345 · NIDCD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DRONKERS, NINA F. · 2017 to 2022
$2.8M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG038791NIA NIH HHS T32 AG023481NIA NIH HHS U01 AG052943NIDCD NIH HHS F31 DC009145NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC016291NIDCD NIH HHS R01 DC016345NIDCD NIH HHS R03 DC013403NINDS NIH HHS R01 NS050915NINDS NIH HHS R01 NS100440NINDS NIH HHS R56 NS050915NINDS NIH HHS U54 NS092089
6 · The paper itself

Abstract

Intrinsic connectivity networks (ICNs) identified through task-free fMRI (tf-fMRI) offer the opportunity to investigate human brain circuits involved in language processes without requiring participants to perform challenging cognitive tasks. In this study, we assessed the ability of tf-fMRI to isolate reproducible networks critical for specific language functions and often damaged in primary progressive aphasia (PPA). First, we performed whole-brain seed-based correlation analyses on tf-fMRI data to identify ICNs anchored in regions known for articulatory, phonological, and semantic processes in healthy male and female controls (HCs). We then evaluated the reproducibility of these ICNs in an independent cohort of HCs, and recapitulated their functional relevance with a

Indexed as

LanguageAgedAphasia, Primary ProgressiveBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuroimagingfunctional connectivitylanguage networksprimary progressive aphasiareproducibilityresting-state connectivity

Identifiers

PMID31852732
PMCPMC7002153
OpenAlexW2996259105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.