ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2019
[Reconstruction of tumor clonal haplotypes based on an improved spanning algorithm].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo reconstruct tumor clonal haplotypes based on the third-generation sequencing data to effectively identify tumor heterogeneity.
methodsWe developed an algorithm for extracting somatic mutational event from the mixed tumor data and determining the connection weight of each somatic cell mutation site through the probability function. A reconstruction algorithm of the haplotype was designed based on the maximum spanning tree, and following the principle of inheritance between tumor clones, the connection pattern was determined at each mutation site in the clonal maximum spanning tree in a stepwise manner. The number, ratio and evolution of the sub-clones were estimated using the depth stripping method.
resultsIn the simulation experiments, we analyzed the accuracy of the algorithm based on 4 indexes, namely the coverage, read length, subclone number and somatic variant rate, and the Results demonstrated a good robustness of the algorithm. The Results of the experiments showed that the mean sub-clone haplotypes accuracy exceeded 97%, suggesting that this algorithm significantly outperformed the previous Methods.
conclusionsThe proposed method can accurately reconstruct tumor subclonal haplotypes and clarify the process of tumor clonal evolution, and can thus provide a theoretical basis for tumor heterogeneity research and assist in clinical decision-making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.