ArticleeLife2019
Uncovering the functional anatomy of the human insula during speech.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Glioma surgery with awake language mapping versus generalized anesthesia: a systematic review.Neurosurgical review · 2021Pooled it
- Immediate and long-term effects of speech treatment targets and intensive dosage on Parkinson's disease dysphonia and the speech motor network: Randomized controlled trial.Human brain mapping · 2022Trial
- Frontotemporal network interactions causally support rapid concreteness judgments during reading.PLoS biology · 2026Article
- The Human Insula Reimagined: Single Neurons Respond to Simple Sounds during Passive Listening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Mapping of critical prosodic and phonetic networks in post-stroke apraxia of speech.bioRxiv : the preprint server for biology · 2025Article
- A Rapid Anterior Auditory Processing Stream through the Insulo-parietal Auditory Field in the Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Age-Associated Cortical Thinning in Speech Motor Regions Precedes Hippocampal Decline: Implications for Alzheimer's Disease.Human brain mapping · 2025Article
- Structural Connectivity Differences Reflect Microstructural Heterogeneity of the Human Insular Cortex.Human brain mapping · 2025Article
- Lesion correlates of impaired acoustic-phonetic perception after unilateral left hemisphere stroke.Brain : a journal of neurology · 2025Article
- Human insula neurons respond to simple sounds during passive listening.bioRxiv : the preprint server for biology · 2025Article
- Supplementary motor area in speech initiation: A large-scale intracranial EEG evaluation of stereotyped word articulation.iScience · 2025Article
- Neuroimaging Findings for the Overnight Consolidation of Learned Non-native Speech Sounds.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Resting-state functional connectivity changes following audio-tactile speech training.Frontiers in neuroscience · 2025Article
- Spatiotemporal Mapping of Auditory Onsets during Speech Production.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Uncovering Interoceptive Human Insular Lobe Function through Intraoperative Cortical Stimulation-A Review.Brain sciences · 2024Review
- Reading reshapes stimulus selectivity in the visual word form area.bioRxiv : the preprint server for biology · 2024Article
- Involvement of the anterior insula and frontal operculum during wh-question comprehension of wh-in-situ Korean language.PloS one · 2024Article
- What is the cognitive footprint of insular glioma?Frontiers in human neuroscience · 2024Review
- Decision and response monitoring during working memory are sequentially represented in the human insula.iScience · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The contribution of insular cortex to speech production remains unclear and controversial given diverse findings from functional neuroimaging and lesional data. To create a precise spatiotemporal map of insular activity, we performed a series of experiments: single-word articulations of varying complexity, non-speech orofacial movements and speech listening, in a cohort of 27 patients implanted with penetrating intracranial electrodes. The posterior insula was robustly active bilaterally, but after the onset of articulation, during listening to speech and during production of non-speech mouth movements. Preceding articulation there was very sparse activity, localized primarily to the frontal operculum rather than the insula. Posterior insular was active coincident with superior temporal gyrus but was more active for self-generated speech than external speech, the opposite of the superior temporal gyrus. These findings support the conclusion that the insula does not serve pre-articulatory preparatory roles.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.