Evidence map›Paper›PMID 31852444›Full record

Trial reportBMC gastroenterology2019

Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial.

Hua Cai, Yue-Lan Qin, Ze-Ya Shi, Jin-Hui Chen, Min-Jie Zeng, Wei Zhou, Ru-Qun Chen, Zhi-Yuan Chen

3 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 111 papers, 27 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 27 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05309642 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of 12-week Intermittent Calorie Restriction on Liver Fat Content in Comparison With Standard-of-care in Patients With Nonalcoholic Fatty Liver Disease: a Randomized Controlled Trial

TypeinterventionalSponsorEwha Womans University Mokdong HospitalRan2022 to 2023Enrolled72ConditionsNonalcoholic Fatty Liver, Nonalcoholic SteatohepatitisArmsIntermittent calorie restriction, Standard of care
NCT05618626 narecruitingnot on this mapstarted 2021, after this paper: background citation

Cardiovascular Diseases (CVD) and Nonalcoholic Fatty Liver Diseases (NAFLD) Among Gallstone and Cholecystectomy Patients and the Impact of a Novel Diet and Muscle Training Program

TypeinterventionalSponsorPontificia Universidad Catolica de ChileRan2021 to 2025Enrolled300ConditionsNon-Alcoholic Fatty Liver Disease, Gallstone DiseaseArmsPhysical exercise and dietary intervention for NAFLD
NCT06676813 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Alternate Day Fasting Over Standard Medical Management Alone to Reverse Non-alcoholic Steatohepatitis(NASH), A Randomized Controlled Trial. FAST Trial"

TypeinterventionalSponsorInstitute of Liver and Biliary Sciences, IndiaRan2024 to 2025Enrolled72ConditionsNon Alcoholic SteatohepatitisArmsAlternate day fasting
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 27 syntheses or guidelines pooled it, 198 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Pooled it
  20. Pooled it

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hua CaiDepartment of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.
Yue-Lan QinDepartment of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.
Ze-Ya ShiDepartment of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.
Jin-Hui ChenDepartment of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.
Min-Jie ZengDepartment of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.
Wei ZhouDepartment of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.
Ru-Qun ChenDepartment of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.
Zhi-Yuan ChenDepartment of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China. chenzhiyuan@hunnu.edu.cn.
Hunan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlternate-day fasting (ADF) is a novel diet therapy that may achieve reduction in body weight and improvement of dyslipidaemia, but the impact of this diet on patients with non-alcoholic fatty liver disease (NAFLD) remains unknown. The aim of this study was to evaluate the effects of ADF on the body weight and lipid profile of individuals with NAFLD.

methodsNAFLD patients (n = 271) were randomised to the ADF group, time-restricted feeding (TRF) group, or the control group and subjected to the respective diet for 12 weeks. Anthropometric measurements (body weight, fat mass/fat-free mass) were performed, and plasma lipids were analysed enzymatically.

resultsWithin 4 weeks, the body weight decreased significantly (P < 0.001) in the ADF group by 4.56 ± 0.41 kg (6.1 ± 0.5%) and the TRF group by 3.62 ± 0.65 kg (4.83 ± 0.9%) compared to the control group, and it decreased even more after 12 weeks in both groups (ADF: - 4.04 ± 0.54 kg, 5.4 ± 0.7%; TRF: - 3.25 ± 0.67 kg, 4.3 ± 0.9%). Fat mass was significantly reduced by ADF (- 3.49 ± 0.37 kg; 11 ± 1.2%) and TRF (- 2.91 ± 0.41 kg; 9.6 ± 1.3%), with ADF leading to a further reduction in fat mass after 12 weeks (- 3.48 ± 0.38 kg; 11 ± 1.2%). Total cholesterol was significantly decreased at both time points in the ADF group (- 0.91 ± 0.07 mmol/L; 18.5 ± 1.5%) compared to the control and TRF groups. Both ADF (- 0.64 ± 0.06 mmol/L; 25 ± 1.9%) and TRF (0.58 ± 0.07 mmol/L; 20 ± 1.7%) achieved a significant reduction in serum triglycerides (P < 0.001) after 12 weeks. Changes in fat free mass, HDL, LDL, fasting insulin, glucose, liver stiffness, and systolic or diastolic blood pressure did not differ between the groups.

conclusionsADF appears to be an effective diet therapy for individuals with NAFLD that can achieve weight loss and improvement of dyslipidaemia within a relatively short period of time (4 to 12 weeks). Potential preventive effects of ADF on cardiovascular disease need to be confirmed by future investigations.

trial registrationChiCTR1900024411, this trial was retrospectively registered on July 10, 2019.

Indexed as

FastingFeeding BehaviorWeight LossAdiposityAdultBody CompositionBody WeightCholesterolDyslipidemiasEnergy IntakeFemaleHumansHungerMaleMetabolic DiseasesNon-alcoholic Fatty Liver DiseaseCholesterolTriglyceridesAlternate-day fastingDyslipidaemiaNon-alcoholic fatty liver diseaseWeight loss

Identifiers

PMID31852444
PMCPMC6921505
OpenAlexW2994761268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.