Evidence map›Paper›PMID 31852078›Full record

Observational studyMedicine2019

Association of obesity with the clinicopathological features of thyroid cancer in a large, operative population: A retrospective case-control study.

Sitong Zhao, Xiaomeng Jia, Xiaojing Fan, Ling Zhao, Ping Pang, Yajing Wang, Yukun Luo, Fulin Wang, Guoqing Yang, Xianling Wang and 8 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Analysis of Body Mass Index and Clinicopathological Factors in Patients with Papillary Thyroid Carcinoma.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  14. Thyroid Nodules and Obesity.Life (Basel, Switzerland) · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Sitong ZhaoThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Xiaomeng JiaThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Xiaojing FanThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Ling ZhaoThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Ping PangDepartment of Endocrinology, Hainan Branch of People's Liberation Army General Hospital, Sanya, Hainan.
Yajing WangThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Yukun LuoDepartment of Ultrasonography, The First Medical Center of People's Liberation Army General Hospital.
Fulin WangDepartment of Pathology, The First Medical Center of People's Liberation Army General Hospital, Beijing, China.
Guoqing YangThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Xianling WangThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Weijun GuThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Li ZangThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Yu PeiThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Jin DuThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Jianming BaThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Jingtao DouThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Yiming MuThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Zhaohui LyuThe Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of People's Liberation Army General Hospital, Beijing.
Chinese General Hospital College of Nursing and Liberal Arts · PHHainan 301 Hospital · CNPeople's Liberation Army No. 150 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate the association between excess body mass index (BMI) and papillary thyroid cancer (PTC) in an operative population, and the impact of higher BMI on clinicopathological aggressiveness of PTC.Charts of 10,844 consecutive patients with thyroid nodules undergoing partial or total thyroidectomy between 1993 and 2015 were reviewed. Patients diagnosed with PTC were stratified in 4 groups: BMI < 18.5 (underweight), 18.5 ≤ BMI < 24 (normal-weight), 24 ≤ BMI < 28 (overweight) and BMI ≥ 28(obese). The impacts of high BMI on prevalence and clinicopathological parameters of PTC were retrospectively analyzed in both univariate and multivariate binary logistic regression analysis.For every 5-unit increase in body mass, the odds of risk-adjusted malignance increased by 36.6%. The individuals who were obese and overweight were associated with high risk of thyroid cancer [odds ratio (OR)= 1.982, P < .001; OR= 1.377, P < .001; respectively] compared to normal weight patients, and this positive association was found in both genders. Obesity was independent predictors for tumors larger than 1 cm (OR = 1.562, P < .001) and multifocality (OR = 1.616, P < .001). However, there was no difference in cervical lymph node (LN) metastasis among BMI groups. Crude analysis showed BMI was associated with advanced tumor-node-metastasis (TNM) stage (relative risk, approximately 1.23 per 5 BMI units, P < .001), but this association disappeared after adjusting for confounding factors.Obesity was significantly associated with the risk of PTC in a large, operative population. Higher BMI was significantly associated with larger tumor size and multifocal tumor.

Indexed as

Body Mass IndexCase-Control StudiesChinaFemaleHumansIncidenceMaleMiddle AgedObesityRetrospective StudiesThyroid Cancer, PapillaryThyroidectomyThyroid Neoplasms

Identifiers

PMID31852078
PMCPMC6922396
OpenAlexW2995600027

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.