Evidence map›Paper›PMID 31851988›Full record

ReviewBlood purification2020

Using Bioimpedance Spectroscopy to Assess Volume Status in Dialysis Patients.

Frank M van der Sande, Esther R van de Wal-Visscher, Stefano Stuard, Ulrich Moissl, Jeroen P Kooman

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Blood purification, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
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  12. Future lines of research on phase angle: Strengths and limitations.Reviews in endocrine & metabolic disorders · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Frank M van der SandeDivision of Nephrology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Esther R van de Wal-VisscherDivision of Nephrology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Stefano StuardClinical and Therapeutical Governance-Care Value Management, Fresenius Medical Care Deutschland, Bad Homburg, Germany.
Ulrich MoisslGlobal Research and Development, Fresenius Medical Care Deutschland, Bad Homburg, Germany.
Jeroen P KoomanDivision of Nephrology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands, jeroen.kooman@mumc.nl.
Fresenius Medical Care (Germany) · DEMaastricht University · NLMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the paper is to reflect on the current status of bioimpedance spectroscopy (BIS) in fluid management in dialysis patients. BIS identifies fluid overload (FO) as a virtual (overhydration) compartment, which is calculated from the difference between the measured extracellular volume and the predicted values based on a fixed hydration of lean and adipose tissue mass. FO is highly prevalent in both hemodialysis (HD) and peritoneal dialysis (PD) patients, while levels of FO are at a population level comparable between PD patients and HD patients when measured before the dialysis treatment. Even mild levels of FO are independently related to outcome in patients on HD, PD as well as in nondialysis patients with advanced chronic kidney disease. FO is not only related to left ventricular hypertrophy (LVH) but also forms part of a multidimensional spectrum with noncardiovascular risk factors such as malnutrition and inflammation. Even after multiple adjustments, FO remains an independent predictor of mortality. BIS-assisted adjustment of dry weight in HD patients has been shown to improve hypertension control and LVH and has resulted in a decline in intradialytic symptomatology. On the other hand, with increased fluid removal, target weight may not always be reached due to an increase in intradialytic symptomatology, and care should be applied in target weight adjustment in fluid overloaded patients with severe malnutrition and/or inflammation. Although a reduction in hospitalization rate was suggested, the effect of BIS-guided dry weight adjustment on mortality has not yet been shown, however, although available studies are underpowered. In PD patients, results have been more equivocal, which may be partly related to differences in treatment protocols or study populations. Future large-scale studies are needed to assess the full potential of BIS.

Indexed as

Blood VolumeDielectric SpectroscopyHypotensionModels, BiologicalWater-Electrolyte ImbalanceHumansRenal DialysisBioimpedanceBlood pressureDialysisOutcomeVolume control

Identifiers

PMID31851988
PMCPMC7114899
OpenAlexW2996465366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.