ReviewBlood purification2020
Microcirculation: Physiology, Pathophysiology, and Clinical Application.
Review in Blood purification, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed, 1 synthesis or guideline pooled it, 246 citations in OpenAlex.
- Ocular markers of microangiopathy and their possible association with cardiovascular risk in patients with systemic inflammatory rheumatic diseases: a systematic review.Frontiers in immunology · 2025Pooled it
- Sublingual microcirculatory assessment on admission independently predicts the outcome of old intensive care patients suffering from shock.Scientific reports · 2024Trial
- Direct assessment of microcirculation in shock: a randomized-controlled multicenter study.Intensive care medicine · 2023Trial
- Diabetic cerebral microvascular disorder: from key pathologies to targeted interventions.Annals of medicine · 2026Review
- Parameters characteristic of upper dermal microvasculature in patients after hematopoietic cell transplantation by noninvasive reflectance confocal videomicroscopy.Microvascular research · 2026Article
- High-Dose MK-801 Attenuated Early TTC-Defined Cortical Injury Even under the Conditions of Suppressed Rapamycin-Sensitive pS6 Signaling during Early Cerebral Ischemia-Reperfusion.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Regional tissue perfusion index (RTPI): a new optical-based metric for quantifying regional tissue perfusion.Journal of clinical monitoring and computing · 2026Article
- A multi-organ atlas of microcirculatory signatures for systemic profiling of diabetic and therapeutic states.Scientific data · 2026Article
- The Beauty Health Index (BHI): A Proposed Framework for Quantifying Facial Aesthetic Health.Cureus · 2026Review
- Comparison of norepinephrine with a combined non-catecholaminergic therapy in a porcine model of refractory cardiac arrest resuscitated with VA-ECMO.Intensive care medicine experimental · 2026Article
- Acute Effects of Percussive Therapy on Thigh Muscle Microcirculation and Oxygenation.Journal of functional morphology and kinesiology · 2026Article
- Review
- Less-Invasive Hemodynamic and Tissue Perfusion Monitoring in Sepsis and Septic Shock: A Narrative Review.Journal of clinical medicine · 2026Review
- Article
- Microvascular phenotypes in pediatric sepsis identified by machine learning: prognostic implications for organ dysfunction and mortality.Critical care (London, England) · 2026Article
- Physiological determinants and the red blood cells transfusion decision-making process in non-bleeding critically ill patients: a comprehensive narrative review.Intensive care medicine · 2026Review
- Protective Effects of Pentoxifylline on Peripheral Microcirculatory Dysfunction and Renal Cortical Oxygen Deficiency in a Rat Model of LPS-Induced Sepsis.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- Microcirculatory failure after successful recanalization in ischemic stroke: insights into mechanisms, imaging, and therapeutic strategies.Frontiers in pharmacology · 2026Review
- Bedside measurement of microcirculation in critically ill patients: A scoping review protocol.PloS one · 2026Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper briefly reviews the physiological components of the microcirculation, focusing on its function in homeostasis and its central function in the realization of oxygen transport to tissue cells. Its pivotal role in the understanding of circulatory compromise in states of shock and renal compromise is discussed. Our introduction of hand-held vital microscopes (HVM) to clinical medicine has revealed the importance of the microcirculation as a central target organ in states of critical illness and inadequate response to therapy. Technical and methodological developments have been made in hardware and in software including our recent introduction and validation of automatic analysis software called MicroTools, which now allows point-of-care use of HVM imaging at the bedside for instant availability of functional microcirculatory parameters needed for microcirculatory targeted resuscitation procedures to be a reality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.