Evidence map›Paper›PMID 31851822›Full record

ArticleACS infectious diseases2020

Biofilm Inhibitor Taurolithocholic Acid Alters Colony Morphology, Specialized Metabolism, and Virulence of

Alanna R Condren, Lisa Juliane Kahl, Gabriela Boelter, George Kritikos, Manuel Banzhaf, Lars E P Dietrich, Laura M Sanchez

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  3. Isoferulic acid suppressesFrontiers in microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alanna R CondrenDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, United States.
Lisa Juliane KahlDepartment of Biological Sciences, Columbia University, 617 Fairchild Center, New York, New York 10027, United States.
Gabriela BoelterInstitute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
George KritikosInstitute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Manuel BanzhafInstitute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Lars E P DietrichDepartment of Biological Sciences, Columbia University, 617 Fairchild Center, New York, New York 10027, United States.
Laura M SanchezDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, United States.ORCID 0000-0001-9223-7977
University of Birmingham · GBColumbia University · USUniversity of Illinois Chicago · US

Funding

UIC Program for Interdisciplinary Careers in Women's Health ResearchK12HD055892 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GELLER, STACIE E. · 2007 to 2016
$4.9M
Integration of redox-balancing mechanisms in Pseudomonas aeruginosa biofilmsR01AI103369 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DIETRICH, LARS · 2013 to 2022
$4.1M
NIAID NIH HHS R01 AI103369NICHD NIH HHS K12 HD055892
6 · The paper itself

Abstract

Biofilm inhibition by exogenous molecules has been an attractive strategy for the development of novel therapeutics. We investigated the biofilm inhibitor taurolithocholic acid (TLCA) and its effects on the specialized metabolism, virulence, and biofilm formation of the clinically relevant bacterium

Indexed as

Anti-Bacterial AgentsBiofilmsMetabolic Networks and PathwaysPseudomonas aeruginosaTaurolithocholic AcidVirulenceAnti-Bacterial AgentsTaurolithocholic Acidbile acidbiofilmsPseudomonas aeruginosataurolithocholic acidvirulence

Identifiers

PMID31851822
PMCPMC7150652
OpenAlexW2994905734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.