ArticleAnnals of surgery2020
Health Care Spending and New Persistent Opioid Use After Surgery.
Article in Annals of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04805229 (Using Difference-in-Differences to Evaluate the Effect of a Statewide Quality Improvement Program on New Persistent Opioid Use After Surgery), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Difference-in-Differences to Evaluate the Effect of a Statewide Quality Improvement Program on New Persistent Opioid Use After Surgery
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Patient-related risk factors for new persistent opioid use after surgery among opioid-naïve individuals in the United States: a systematic review and meta-analysis.Pain medicine (Malden, Mass.) · 2026Pooled it
- Analgesic efficacy of an opioid-free postoperative pain management strategy versus a conventional opioid-based strategy following laparoscopic radical gastrectomy: an open-label, randomized, controlled, non-inferiority trial.World journal of surgical oncology · 2024Trial
- Effect of transauricular nerve stimulation on perioperative pain: a single-blind, analyser-masked, randomised controlled trial.British journal of anaesthesia · 2023Trial
- Effect of oxycodone vs. morphine as first-line opioid on new persistent opioid use after orthopaedic surgery: A prospective sequential cohort study.British journal of clinical pharmacology · 2026Article
- Impact of preoperative opioid exposure on cost of care and workplace productivity loss after elective surgery.Regional anesthesia and pain medicine · 2026Article
- Persistent Opioid Use Following Major Orthopedic Surgery.Current pain and headache reports · 2025Review
- Development of an implementation intervention to promote adoption of the COMFORT clinical practice guideline for peripartum pain management: a qualitative study.Implementation science communications · 2025Article
- Intravenous lidocaine reduces pain intensity and attenuates the increase in plasma norepinephrine levels after hysterectomy.Qatar medical journal · 2025Article
- Characterizing patterns of opioid prescribing after outpatient ventral hernia repair with mesh.Hernia : the journal of hernias and abdominal wall surgery · 2024Review
- Perioperative Opioid-Related Harms: Opportunities to Minimize Risk.Seminars in plastic surgery · 2024Review
- Is outpatient spine surgery associated with new, persistent opioid use in opioid-naïve patients? A retrospective national claims database analysis.The spine journal : official journal of the North American Spine Society · 2023Article
- Long-term Health Outcomes of New Persistent Opioid Use After Surgery Among Medicare Beneficiaries.Annals of surgery · 2023Article
- Analgesic efficacy of an opioid-free postoperative pain management strategy versus a conventional opioid-based strategy following open major hepatectomy: an open-label, randomised, controlled, non-inferiority trial.EClinicalMedicine · 2023Article
- Postoperative Opioid Prescribing and New Persistent Opioid Use: The Risk of Excessive Prescribing.Annals of surgery · 2023Article
- Early reduction in postoperative pain is associated with improved long-term function after shoulder arthroplasty: a retrospective case series.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Article
- Higher Pain Catastrophizing and Preoperative Pain is Associated with Increased Risk for Prolonged Postoperative Opioid Use.Pain physician · 2023Observational
- New chronic opioid use in Medicaid patients following cholecystectomy.Surgery open science · 2022Article
- Dynamics of Acute Postsurgical Pain over the Last Decade: A Bibliometric Analysis.Pain research & management · 2022Review
- Predicting postoperative opioid use with machine learning and insurance claims in opioid-naïve patients.American journal of surgery · 2021Article
- New and persistent controlled substance use among patients undergoing mastectomy and reconstructive surgery.Breast cancer research and treatment · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveWe sought to describe the differences in health care spending and utilization among patients who develop persistent postoperative opioid use. SUMMARY OF BACKGROUND DATA: Although persistent opioid use following surgery has garnered concern, its impact on health care costs and utilization remains unknown.
methodsWe examined insurance claims among 133,439 opioid-naive adults undergoing surgery. Outcomes included 6-month postoperative health care spending; proportion of spending attributable to admission, readmission, ambulatory or emergency care; monthly spending 6 months before and following surgery. We defined persistent opioid use as continued opioid fills beyond 3 months postoperatively. We used linear regression to estimate outcomes adjusting for clinical covariates.
resultsIn this cohort, 8103 patients developed persistent opioid use. For patients who underwent inpatient procedures, new persistent opioid use was associated with health care spending (+$2700 per patient, P < 0.001) compared with patients who did not develop new persistent use. For patients who underwent outpatient procedures, new persistent opioid use was similarly correlated with higher health care spending (+$1500 per patient, P < 0.001) compared with patients who did not develop new persistent use. Patients without persistent opioid use returned to baseline health care spending within 6 months, regardless of other complications. However, patients with persistent opioid use had sustained increases in spending by approximately $200 per month.
conclusionUnlike other postoperative complications, persistent opioid use is associated with sustained increases in spending due to greater readmissions and ambulatory care visits. Early identification of patients vulnerable to persistent use may enhance the value of surgical care.
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Registered trials
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