Evidence map›Paper›PMID 31851597›Full record

ArticleMolecular biology of the cell2020

Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation.

Jill B Graham, Johan C Sunryd, Ketan Mathavan, Emma Weir, Ida Signe Bohse Larsen, Adnan Halim, Henrik Clausen, Hélène Cousin, Dominque Alfandari, Daniel N Hebert

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Glycan-related genes and genetic disorders.Journal of human genetics · 2026
    Review
  4. Review
  5. Article
  6. Prognostic value ofHeliyon · 2024
    Article
  7. Article
  8. Notch transcriptional target tmtc1 maintains vascular homeostasis.Cellular and molecular life sciences : CMLS · 2024
    Article
  9. Review
  10. Article
  11. The SHDRA syndrome-associated geneProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Human ArylamineFrontiers in pharmacology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jill B GrahamDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Amherst, MA 01003.
Johan C SunrydDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Amherst, MA 01003.
Ketan MathavanProgram in Molecular and Cellular Biology, University of Massachusetts, Amherst, Amherst, MA 01003.
Emma WeirProgram in Molecular and Cellular Biology, University of Massachusetts, Amherst, Amherst, MA 01003.
Ida Signe Bohse LarsenDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark.
Adnan HalimDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark.
Henrik ClausenDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark.
Hélène CousinProgram in Molecular and Cellular Biology, University of Massachusetts, Amherst, Amherst, MA 01003.
Dominque AlfandariProgram in Molecular and Cellular Biology, University of Massachusetts, Amherst, Amherst, MA 01003.
Daniel N HebertDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Amherst, MA 01003.
University of Massachusetts Amherst · USUniversity of Copenhagen · DK

Funding

Cellular protein maturation and degradationR01GM086874 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI RAUCH, JENNIFER NICOLE · 2009 to 2025
$4.5M
CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
NIGMS NIH HHS R01 GM086874NIGMS NIH HHS T32 GM008515
6 · The paper itself

Abstract

Protein glycosylation plays essential roles in protein structure, stability, and activity such as cell adhesion. The cadherin superfamily of adhesion molecules carry O-linked mannose glycans at conserved sites and it was recently demonstrated that the

Indexed as

AnimalsCadherinsCarrier ProteinsCell AdhesionCell Adhesion MoleculesChlorocebus aethiopsCOS CellsEndoplasmic ReticulumGastrulationGlycosylationHEK293 CellsHumansMannoseMembrane ProteinsMutationNeuronsCadherinsCarrier ProteinsCell Adhesion MoleculesMannoseMembrane ProteinsTMTC1 protein, humanTMTC3 protein, human

Identifiers

PMID31851597
PMCPMC7001481
OpenAlexW2995400160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.