Evidence map›Paper›PMID 31851575›Full record

ArticleEpigenetics2020

The dynamics of DNA methylation during epigenetic reprogramming of primordial germ cells in medaka (

Xuegeng Wang, Ramji Kumar Bhandari

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Epigenetic editing of marine medaka (Zoological research · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Fish reproduction in a warming world: vulnerable points in hormone regulation from sex determination to spawning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Germline stem cells in human.Signal transduction and targeted therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xuegeng WangDepartment of Biology, University of North Carolina Greensboro, Greensboro, NC, USA.
Ramji Kumar BhandariDepartment of Biology, University of North Carolina Greensboro, Greensboro, NC, USA.ORCID 0000-0001-5608-7254
University of North Carolina at Greensboro · US

Funding

Germline transmission of epigenetic alterations to offspringR01ES032452 · NIEHS · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Ramji Kumar Bhandari · 2022 to 2026
$1.7M
Germline transmission of epigenetic alterations to offspring induced by bisphenol A exposureR21ES027123 · NIEHS · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI BHANDARI, RAMJI KUMAR · 2017 to 2019
$490k
Correction of endocrine disruptor-induced transgenerational epimutations by CRISPR-dCas9R21HD098621 · NICHD · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI BHANDARI, RAMJI KUMAR · 2020 to 2021
$400k
NICHD NIH HHS R21 HD098621NIEHS NIH HHS R01 ES032452NIEHS NIH HHS R21 ES027123
6 · The paper itself

Abstract

Primordial germ cells (PGCs) are precursors of eggs and sperm. How the PGCs epigenetically reprogram during early embryonic development in fish is currently unknown. Here we generated a series of PGC methylomes using whole genome bisulfite sequencing across key stages from 8 days post fertilization (dpf) to 25 dpf coinciding with germ cell sex determination and gonadal sex differentiation in medaka (

Indexed as

Cellular ReprogrammingDNA MethylationEpigenesis, GeneticAnimalsCpG IslandsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BFish ProteinsGametogenesisGerm CellsOryziasPromoter Regions, GeneticDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BFish ProteinsDNA methylationEpigenetic reprogrammingmedakaprimordial germ cells

Identifiers

PMID31851575
PMCPMC7188396
OpenAlexW2995514573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.