Evidence map›Paper›PMID 31851318›Full record

ArticleBiostatistics (Oxford, England)2021

Covariate Assisted Principal regression for covariance matrix outcomes.

Yi Zhao, Bingkai Wang, Stewart H Mostofsky, Brian S Caffo, Xi Luo

Abstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Connectivity Regression.Biostatistics (Oxford, England) · 2025
    Article
  3. Article
  4. Mediation analysis with graph mediator.Biostatistics (Oxford, England) · 2025
    Article
  5. Article
  6. Wasserstein F-tests for Fréchet regression on Bures-Wasserstein manifolds.Journal of machine learning research : JMLR · 2025
    Article
  7. Article
  8. Article
  9. Longitudinal regression of covariance matrix outcomes.Biostatistics (Oxford, England) · 2024
    Article
  10. Article
  11. Article
  12. Genetic underpinnings of brain structural connectome for young adults.Journal of the American Statistical Association · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi ZhaoDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA and Department of Biostatistics, Indiana University School of Medicine, 410 W 10th St, Indianapolis, IN 46202, USA.
Bingkai WangDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA.
Stewart H MostofskyCenter for Neurodevelopmental and Imaging Research (CNIR) at Kennedy Krieger Institute, Johns Hopkins University, 707 N Broadway, Baltimore, MD 21205, USA.
Brian S CaffoDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA.
Xi LuoDepartment of Biostatistics and Data Science, The University of Texas Health Science Center at Houston, 1200 Pressler St, Houston, TX 77030, USA.

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
Neurology of Deficient Response Control in ADHDR01MH085328 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2009 to 2019
$7.3M
Large-scale Network Modeling for Brain Dynamics: Statistical Learning and OptimizationR01EB022911 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LUO, XI · 2016 to 2018
$1.2M
NICHD NIH HHS P50 HD103538NIMH NIH HHS R01 MH085328
6 · The paper itself

Abstract

In this study, we consider the problem of regressing covariance matrices on associated covariates. Our goal is to use covariates to explain variation in covariance matrices across units. As such, we introduce Covariate Assisted Principal (CAP) regression, an optimization-based method for identifying components associated with the covariates using a generalized linear model approach. We develop computationally efficient algorithms to jointly search for common linear projections of the covariance matrices, as well as the regression coefficients. Under the assumption that all the covariance matrices share identical eigencomponents, we establish the asymptotic properties. In simulation studies, our CAP method shows higher accuracy and robustness in coefficient estimation over competing methods. In an example resting-state functional magnetic resonance imaging study of healthy adults, CAP identifies human brain network changes associated with subject demographics.

Indexed as

AlgorithmsMagnetic Resonance ImagingBrainComputer SimulationHumansLinear ModelsCommon diagonalizationHeteroscedasticityLinear projection

Identifiers

PMID31851318
PMCPMC8286560

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.