ArticleJournal of neuropathology and experimental neurology2020
Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity.
Article in Journal of neuropathology and experimental neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Traumatic brain injury and late-life Alzheimer's disease neuropathology: Quantitative investigation in the Adult Changes in Thought study.Journal of Alzheimer's disease : JAD · 2026Article
- Traumatic brain injury and risk of early-onset dementia: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Tau-PET imaging and blood biomarkers reveal early tauopathy in special operations forces exposed to repetitive blast.Brain communications · 2026Article
- Ante-Mortem Clinical Characterization with Post-Mortem Family Interview and Medical Record Abstraction in a Traumatic Brain Injury Brain Donor Program.Neurotrauma reports · 2025Article
- Increased [Journal of neurotrauma · 2024Article
- Association between military service and Alzheimer's disease neuropathology at autopsy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neuroinflammation at the Gray-White Matter Interface in Active-Duty U.S. Special Operations Forces.Neurotrauma reports · 2024Article
- Double Blast Wave Primary Effect on Synaptic, Glymphatic, Myelin, Neuronal and Neurovascular Markers.Brain sciences · 2023Article
- Migration and Cognitive Health Disparities: The Arab American and Refugee Case.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Association of Traumatic Brain Injury with Late Life Neuropathological Outcomes in a Community-Based Cohort.Journal of Alzheimer's disease : JAD · 2023Article
- Traumatic Brain Injury and Risk of Neurodegenerative Disorder.Biological psychiatry · 2022Review
- Blood-Based Biomarkers for Alzheimer's Disease in Older Adults with Posttraumatic Stress Disorder.Journal of Alzheimer's disease reports · 2022Article
- Phenotyping the Spectrum of Traumatic Brain Injury: A Review and Pathway to Standardization.Journal of neurotrauma · 2021Review
- Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.Acta neuropathologica communications · 2021Article
- The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy.Journal of neuropathology and experimental neurology · 2021Article
- Repeated Low-Level Blast Acutely Alters Brain Cytokines, Neurovascular Proteins, Mechanotransduction, and Neurodegenerative Markers in a Rat Model.Frontiers in cellular neuroscience · 2021Article
- Psychological Stress-Induced Immune Response and Risk of Alzheimer's Disease in Veterans from Operation Enduring Freedom and Operation Iraqi Freedom.Clinical therapeutics · 2020Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
The neuropathology associated with cognitive decline in military personnel exposed to traumatic brain injury (TBI) and chronic stress is incompletely understood. Few studies have examined clinicopathologic correlations between phosphorylated-tau neurofibrillary tangles, β-amyloid neuritic plaques, neuroinflammation, or white matter (WM) lesions, and neuropsychiatric disorders in veterans. We describe clinicopathologic findings in 4 military veterans with early-onset dementia (EOD) who had varying histories of blunt- and blast-TBI, cognitive decline, behavioral abnormalities, post-traumatic stress disorder, suicidal ideation, and suicide. We found that pathologic lesions in these military-EOD cases could not be categorized as classic Alzheimer's disease (AD), chronic traumatic encephalopathy, traumatic axonal injury, or other well-characterized clinicopathologic entities. Rather, we observed a mixture of polypathology with unusual patterns compared with pathologies found in AD or other dementias. Also, ultrahigh resolution ex vivo MRI in 2 of these 4 brains revealed unusual patterns of periventricular WM injury. These findings suggest that military-EOD cases are associated with atypical combinations of brain lesions and distribution rarely seen in nonmilitary populations. Future prospective studies that acquire neuropsychiatric data before and after deployments, as well as genetic and environmental exposure data, are needed to further elucidate clinicopathologic correlations in military-EOD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.