Evidence map›Paper›PMID 31851211›Full record

ArticleActa cirurgica brasileira2019

The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 431.

Alexandre Maximiliano Trevisan, Bruno Cogliati, Adriana Ribeiro Homem, Thiago Pinheiro Arrais Aloiav, Nelson de Aquino Neto, Jairo Marques Moreira, Leonardo da Cruz Reno, Alexandre Moulin Naumann, Flavio Henrique Ferreira Galvão, Wellington Andraus and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alexandre Maximiliano TrevisanFellow PhD degree and MSc degree, Postgraduate Program in Medicine Science in Gastroenterology, Department of Gastroenterology, School of Medicine, Medical Investigation Laboratory (LIM 37), Universidade de São Paulo (USP), Brazil. Technical procedures, acquisition of data, statistical analysis, manuscript writing.ORCID http://orcid.org/0000-0001-6430-3199
Bruno CogliatiPhD, Department of Pathology, School of Veterinary Medicine and Animal Science, USP, Sao Paulo-SP, Brazil. Technical procedures.ORCID http://orcid.org/0000-0002-1388-7240
Adriana Ribeiro HomemPhD, Department of Gastroenterology, School of Medicine, Medical Investigation Laboratory (LIM 37), USP, Sao Paulo-SP, Brazil. Manuscript writing.ORCID http://orcid.org/0000-0001-7646-1354
Thiago Pinheiro Arrais AloiavNursing student, Hospital Albert Einstein, Sao Paulo-SP, Brazil. Technical procedures, acquisition of data.ORCID http://orcid.org/0000-0001-6913-8989
Nelson de Aquino NetoFellow Master degree, Postgraduate Program in Medicine Surgical Gastroenterology, School of Medicine, USP, Sao Paulo-SP, Brazil. Statistical analysis, manuscript writing.ORCID http://orcid.org/0000-0002-8560-6233
Jairo Marques MoreiraBiologist, Hospital Albert Einstein, Sao Paulo-SP, Brazil. Technical procedures, acquisition of data.ORCID http://orcid.org/0000-0002-2642-8414
Leonardo da Cruz RenoFellow Master degree, Postgraduate Program in Medicine Surgical Gastroenterology, School of Medicine, USP, Sao Paulo-SP, Brazil. Technical procedures, acquisition of data, manuscript writing.ORCID http://orcid.org/0000-0002-8806-7845
Alexandre Moulin NaumannFellow Master degree, Postgraduate Program in Medicine Surgical Gastroenterology, School of Medicine, USP, Sao Paulo-SP, Brazil. Technical procedures, acquisition of data, manuscript writing.ORCID http://orcid.org/0000-0002-3521-045X
Flavio Henrique Ferreira GalvãoAssistant Professor, Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, School of Medicine, Coordinator, Medical Investigation Laboratory (LIM 37), USP, Sao Paulo-SP, Brazil. Surgical procedures, manuscript writing, critical revision.ORCID http://orcid.org/0000-0003-1924-3208
Wellington AndrausAssistant Professor, Coordinator, Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, School of Medicine, Medical Investigation Laboratory (LIM 37), USP, Sao Paulo-SP, Brazil. Surgical procedures, manuscript writing, critical revision.ORCID http://orcid.org/0000-0002-5162-138X
Luiz Augusto Carneiro D'AlbuquerqueFull Professor, Chairman, Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, School of Medicine, Medical Investigation Laboratory (LIM 37), USP, Sao Paulo-SP, Brazil. Conception and design of the study, manuscript writing, critical revision.ORCID http://orcid.org/0000-0001-7607-7168
Universidade de São Paulo · BRHospital Israelita Albert Einstein · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury.

methodsWe use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes (AST, ALT, GGT) and histology.

resultsThe mice with Cx43 deficiency showed an ALT mean value of 4166 vs. 307 in the control group (p<0.001); AST mean value of 7231 vs. 471 in the control group (p<0.001); GGT mean value of 9.4 vs. 1.7 in the control group (p=0.001); histology showed necrosis and inflammation in the knockout group.

conclusionsThis research demonstrated that the deficiency of Cx43 worses the prognosis for liver injury. The topic is a promising target for therapeutics advancements in liver diseases and procedures.

Indexed as

Disease Models, AnimalAlanine TransaminaseAnimalsAspartate AminotransferasesConnexin 43gamma-GlutamyltransferaseGenotyping TechniquesLiverMice, KnockoutNecrosisPolymerase Chain ReactionReference ValuesReperfusion InjuryTime FactorsAlanine TransaminaseAspartate AminotransferasesConnexin 43gamma-GlutamyltransferaseGJA1 protein, mouse

Identifiers

PMID31851211
PMCPMC6912844
OpenAlexW2995700783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.