ArticleeLife2019
Catecholaminergic modulation of meta-learning.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance.eLife · 2025Trial
- The Computational, Pharmacological, and Physiological Determinants of Sensory Learning under Uncertainty.Current biology : CB · 2021Trial
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- Orbitofrontal noradrenaline supports adaptive learning-rate adjustment in probabilistic reversal learning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Differential Impact of Social and Non-social Cues on Decision-making Across At-risk Mental State, Early Psychosis, and Healthy Participants.Schizophrenia bulletin open · 2026Article
- Noradrenergic alpha-2a receptor stimulation enhances prediction error signaling and updating of attention sets in anterior cingulate cortex and striatum.Nature communications · 2024Article
- Learning environment-specific learning rates.PLoS computational biology · 2024Article
- Two Determinants of Dynamic Adaptive Learning for Magnitudes and Probabilities.Open mind : discoveries in cognitive science · 2024Article
- Noradrenergic alpha-2a Receptor Stimulation Enhances Prediction Error Signaling in Anterior Cingulate Cortex and Striatum.bioRxiv : the preprint server for biology · 2023Article
- A boost in self-esteem after positive social evaluation predicts social and non-social learning.Royal Society open science · 2023Article
- Adaptive tuning of human learning and choice variability to unexpected uncertainty.Science advances · 2023Article
- Dopaminergic challenge dissociates learning from primary versus secondary sources of information.eLife · 2022Article
- A Computational Model of Hopelessness and Active-Escape Bias in Suicidality.Computational psychiatry (Cambridge, Mass.) · 2022Article
- Meta-control: From psychology to computational neuroscience.Cognitive, affective & behavioral neuroscience · 2021Review
- Catecholaminergic modulation of meta-learning.eLife · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The remarkable expedience of human learning is thought to be underpinned by meta-learning, whereby slow accumulative learning processes are rapidly adjusted to the current learning environment. To date, the neurobiological implementation of meta-learning remains unclear. A burgeoning literature argues for an important role for the catecholamines dopamine and noradrenaline in meta-learning. Here, we tested the hypothesis that enhancing catecholamine function modulates the ability to optimise a meta-learning parameter (learning rate) as a function of environmental volatility. 102 participants completed a task which required learning in stable phases, where the probability of reinforcement was constant, and volatile phases, where probabilities changed every 10-30 trials. The catecholamine transporter blocker methylphenidate enhanced participants' ability to adapt learning rate: Under methylphenidate, compared with placebo, participants exhibited higher learning rates in volatile relative to stable phases. Furthermore, this effect was significant only with respect to direct learning based on the participants' own experience, there was no significant effect on inferred-value learning where stimulus values had to be inferred. These data demonstrate a causal link between catecholaminergic modulation and the adjustment of the meta-learning parameter learning rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.