ArticleNature electronics2019
A miniaturized multi-clamp CMOS amplifier for intracellular neural recording.
Article in Nature electronics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Time for NanoNeuro.Nature methods · 2021Review
- Frequency-Division Multiplexing with Graphene Active Electrodes for Neurosensor Applications.IEEE transactions on circuits and systems. II, Express briefs : a publication of the IEEE Circuits and Systems Society · 2021Article
- A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection.Microsystems & nanoengineering · 2021Article
- Single neuron recording: progress towards high-throughput analysis.Bioelectronics in medicine · 2020Article
- Sputtered porous Pt for wafer-scale manufacture of low-impedance flexible microelectrodes.Journal of neural engineering · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Intracellular electrophysiology is a foundational method in neuroscience and uses electrolyte-filled glass electrodes and benchtop amplifiers to measure and control transmembrane voltages and currents. Commercial amplifiers perform such recordings with high signal-to-noise ratios (SNRs) but are often expensive, bulky, and not easily scalable to many channels due to reliance on board-level integration of discrete components. Here, we present a monolithic complementary-metal-oxide-semiconductor (CMOS) multi-clamp amplifier integrated circuit capable of recording both voltages and currents with performance exceeding that of commercial benchtop instrumentation. Miniaturization enables high-bandwidth current mirroring, facilitating the synthesis of large-valued active resistors with lower noise than their passive equivalents. This enables the realization of compensation modules that can account for a wide range of electrode impedances. We validate the amplifier's operation electrically, in primary neuronal cultures, and in acute slices, using both high-impedance sharp and patch electrodes. This work provides a solution for low-cost, high-performance and scalable multi-clamp amplifiers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.