Evidence map›Paper›PMID 31850325›Full record

ArticleFrontiers in bioengineering and biotechnology2019

Three-Layered Silk Fibroin Tubular Scaffold for the Repair and Regeneration of Small Caliber Blood Vessels: From Design to

Antonio Alessandrino, Anna Chiarini, Marco Biagiotti, Ilaria Dal Prà, Giulia A Bassani, Valentina Vincoli, Piergiorgio Settembrini, Pasquale Pierimarchi, Giuliano Freddi, Ubaldo Armato

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 63 citations in OpenAlex.

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  6. Silk fibroin-based scaffolds for tissue engineering.Frontiers in bioengineering and biotechnology · 2024
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  17. Silk fibroin scaffolds: A promising candidate for bone regeneration.Frontiers in bioengineering and biotechnology · 2022
    Review
  18. Electrospun nanofiber scaffold for vascular tissue engineering.Materials science & engineering. C, Materials for biological applications · 2021
    Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Antonio AlessandrinoSilk Biomaterials Srl, Lomazzo, Italy.
Anna ChiariniHuman Histology & Embryology Section, Department of Surgery, Dentistry, Pediatrics & Gynecology, University of Verona Medical School, Verona, Italy.
Marco BiagiottiSilk Biomaterials Srl, Lomazzo, Italy.
Ilaria Dal PràHuman Histology & Embryology Section, Department of Surgery, Dentistry, Pediatrics & Gynecology, University of Verona Medical School, Verona, Italy.
Giulia A BassaniSilk Biomaterials Srl, Lomazzo, Italy.
Valentina VincoliSilk Biomaterials Srl, Lomazzo, Italy.
Piergiorgio SettembriniDepartment of Vascular Surgery, San Carlo Borromeo Hospital, Milan, Italy.
Pasquale PierimarchiInstitute of Translational Pharmacology, National Research Council, Rome, Italy.
Giuliano FreddiSilk Biomaterials Srl, Lomazzo, Italy.
Ubaldo ArmatoHuman Histology & Embryology Section, Department of Surgery, Dentistry, Pediatrics & Gynecology, University of Verona Medical School, Verona, Italy.
Institute of Polymers, Composites and Biomaterials · ITUniversity of Verona · ITIstituto di Farmacologia Traslazionale · ITOspedale San Carlo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silk fibroin (SF) is an eligible biomaterial for the development of small caliber vascular grafts for substitution, repair, and regeneration of blood vessels. This study presents the properties of a newly designed multi-layered SF tubular scaffold for vascular grafting (SilkGraf). The wall architecture consists of two electrospun layers (inner and outer) and an intermediate textile layer. The latter was designed to confer high mechanical performance and resistance on the device, while electrospun layers allow enhancing its biomimicry properties and host's tissues integration.

Indexed as

in vitro biocompatibilityin vivo pilot testmechanical performancemorphological structuresilk fibroinsmall caliber vascular graft

Identifiers

PMID31850325
PMCPMC6895545
OpenAlexW2990907640

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.