Evidence map›Paper›PMID 31850230›Full record

ArticleFrontiers in oncology2019

Effective MR Molecular Imaging of Triple Negative Breast Cancer With an EDB-Fibronectin-Specific Contrast Agent at Reduced Doses.

Nadia R Ayat, Amita Vaidya, Grace A Yeung, Megan N Buford, Ryan C Hall, Peter L Qiao, Xin Yu, Zheng-Rong Lu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  5. PET Imaging of Hepatocellular Carcinoma Using ZD2-(Journal of hepatocellular carcinoma · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nadia R AyatDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, OH, United States.
Amita VaidyaDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, OH, United States.
Grace A YeungDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, OH, United States.
Megan N BufordDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, OH, United States.
Ryan C HallDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, OH, United States.
Peter L QiaoDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, OH, United States.
Xin YuDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, OH, United States.
Zheng-Rong LuDepartment of Biomedical Engineering, School of Engineering, Case Western Reserve University, Cleveland, OH, United States.
Case Western Reserve University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
NRSA Training CoreTL1TR002549 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI HARDING, CLIFFORD V · 2018 to 2022
$2.9M
Image-guided EMT inhibition for treating metastatic breast cancerR01CA194518 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI LU, ZHENG-RONG, SCHIEMANN, WILLIAM · 2015 to 2019
$2.4M
Targeted MRI contrast agents for differential diagnosis of prostate cancerR01CA211762 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI LU, ZHENG-RONG · 2017 to 2021
$2.1M
NCATS NIH HHS TL1 TR002549NCI NIH HHS R01 CA194518NCI NIH HHS R01 CA211762NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

MR molecular imaging (MRMI) of abundant oncogenic biomarkers in tumor microenvironment has the potential to provide precision cancer imaging in high resolution. Extradomain-B fibronectin (EDB-FN) is an oncogenic extracellular matrix protein, highly expressed in aggressive triple negative breast cancer. A targeted macrocyclic gadolinium-based contrast agent (GBCA) ZD2-N

Indexed as

breast cancerEDB-fibronectinGBCAstargeted MRI contrast agenttumor microenvironment

Identifiers

PMID31850230
PMCPMC6901824
OpenAlexW2989586871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.