ReviewInternational journal of ophthalmology2019
Combined corneal CXL and photorefractive keratectomy for treatment of keratoconus: a review.
Review in International journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Delayed corneal haze after combined photorefractive keratectomy and corneal cross-linking in non-keratoconus patients.International ophthalmology · 2025Article
- Six-Month Outcomes of Accelerated Corneal Cross-Linking with a Total Dose of 7.2 J/cm2 Using Dextran-Free Riboflavin.Korean journal of ophthalmology : KJO · 2025Article
- Demographic and topographic findings suggesting poor response to crosslinking-iontophoresis in patients with progressive keratoconus.International ophthalmology · 2025Article
- Application of Surgical Protocols for the Treatment of Highly Irregular Astigmatism with Topographic Guided Ablation in a Case of Post-LASIK Ectasia.International medical case reports journal · 2025Article
- Progressive Keratoconus Treatment with Transepithelial Two-Step Phototherapeutic Keratectomy Combined with Corneal Crosslinking (CXL): Clinical Outcomes and Postoperative Management Including Potential Complications of the Modified Athens Protocol Designed for US-Approved Excimer Laser Specifications.Journal of clinical medicine · 2024Article
- Effects and safety of combined corneal collagen crosslinking and intrastromal corneal ring segment treatment in patients with keratoconus: a retrospective study.BMC ophthalmology · 2024Article
- Headache Attributed to Refractive Error: Improvement after Topography-Guided Photorefractive Keratectomy with Corneal Cross-Linking in Patients with Keratoconus.Journal of clinical medicine · 2024Article
- Recent Advances in Refractive Surgery: An Overview.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Intraocular pressure after combined photorefractive keratectomy and corneal collagen cross-linking for keratoconus.International ophthalmology · 2023Article
- Determination of efficacy of repeated CXL and probable risk factors in patients with progressive keratoconus.International ophthalmology · 2023Article
- The Impaired Wound Healing Process Is a Major Factor in Remodeling of the Corneal Epithelium in Adult and Adolescent Patients With Keratoconus.Investigative ophthalmology & visual science · 2023Article
- Management of keratoconus: an updated review.Frontiers in medicine · 2023Review
- Recent advances in medicinal compounds related to corneal crosslinking.Frontiers in pharmacology · 2023Review
- Evaluation of the effectiveness of combined staged surgical treatment in patients with keratoconus.PloS one · 2022Article
- Outcomes of Corneal Topographical Kmax readings 3 months after Corneal Cross Linkage in Keratoconus patients.Journal of community hospital internal medicine perspectives · 2022Article
- Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Changes of matrix metalloproteinases in the stroma after corneal cross-linking in rabbits.International journal of ophthalmology · 2021Article
- Excimer laser treatment combined with riboflavin ultraviolet-A (UVA) collagen crosslinking (CXL) in keratoconus: a literature review.International ophthalmology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratoconus and iatrogenic keratectasia are the corneal ectatic disorders occurring due to biomechanical weakening of the cornea resulting in distorted images, myopia, and irregular astigmatism. Corneal collagen cross-linking (CXL) is performed to arrest keratoconus successfully. The main aim of this review is to discuss the safety and efficacy of the adjuvant therapies, such as the combination of CXL and photorefractive keratectomy (PRK) for the treatment of corneal ectatic disorders. A comprehensive literature search was performed using PubMed, MEDLINE, and Scopus using keywords 'collagen' 'keratoconus', 'keratectasia', 'collagen cross-linking', and 'photorefractive keratectomy'. Search results were restricted to clinical studies published in English. Corneal CXL effectively arrests the progression of keratoconus by enhancing corneal rigidity. However, functional vision is not improved by cross-linking. Combining CXL to refractive surgeries such as topography-guided PRK or transepithelial PRK is found to be a safe and effective method in providing corneal stability as well as significantly improving functional visual acuity with few minor complications. This combined technique also prevents regression of keratoconus and reduce the risk of keratectasia. CXL combined with PRK is a promising therapeutic approach in ophthalmology that can be successfully used to treat progressive keratoconus and other corneal ectatic disorders and to enhance visual acuity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.