Evidence map›Paper›PMID 31850103›Full record

ReviewOpen access Macedonian journal of medical sciences2019

Botulin Toxin Use in Scars/Keloids Treatment.

Jacopo Scala, Aleksandra Vojvodic, Petar Vojvodic, Tatjana Vlaskovic-Jovicevic, Zorica Peric-Hajzler, Dusica Matovic, Sanja Dimitrijevic, Jovana Vojvodic, Goran Sijan, Nenad Stepic and 5 more

Open access · diamondAbstract readReview
In one paragraph

Review in Open access Macedonian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. The Latest Advances in Rosacea Treatment: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Review
  4. Potency of bacterial sialidaseVeterinary world · 2022
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Jacopo ScalaUniversity G. Marconi, Rome, Italy.
Aleksandra VojvodicDepartment of Dermatology and Venereology, Military Medical Academy, Belgrade, Serbia.
Petar VojvodicClinic for Psychiatric Disorders "Dr. Laza Lazarevic", Belgrade, Serbia.
Tatjana Vlaskovic-JovicevicClinic for Psychiatric Disorders "Dr. Laza Lazarevic", Belgrade, Serbia.
Zorica Peric-HajzlerMilitary Medical Academy, Belgrade, Serbia.
Dusica MatovicMilitary Medical Academy, Belgrade, Serbia.
Sanja DimitrijevicDepartment of Gynecology, Military Medical Academy, Belgrade, Serbia.
Jovana VojvodicClinic for Psychiatric Disorders "Dr. Laza Lazarevic", Belgrade, Serbia.
Goran SijanClinic for Plastic Surgery and Burns, Military Medical Academy, Belgrade, Serbia.
Nenad StepicChief of Clinic for Plastic Surgery and Burns, Military Medical Academy, Belgrade, Serbia.
Uwe WollinaDepartment of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany.
Michael TirantUniversity G. Marconi, Rome, Italy.
Nguyen Van ThuongVietnam National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
Massimo FioranelliDepartment of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy.
Torello LottiDepartment of Dermatology, University of G. Marconi, Rome, Italy.
Military Medical Academy · RSMarconi University · ITNational Hospital of Pediatrics · VNStädtisches Klinikum Dresden · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Botulinum toxin (BTX) is a neurotoxin protein derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermatological conditions which include scar prevention and treatment with good results The complex mechanism underlying those results is not completely understood but several mechanisms were proposed release inhibition of different substances like (TGF)-β, substance P, calcitonin gene-related peptide (CGRP) and glutamate thus modulating cutaneous inflammation and wound healing. We analysed the published data on BTX off label applications on scars and keloids retrieved from PubMed.

Indexed as

Botulin toxinKeloidsScars

Identifiers

PMID31850103
PMCPMC6910812
OpenAlexW2989814988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.