Evidence map›Paper›PMID 31849995›Full record

ReviewFrontiers in immunology2019

Metabolic Pathways Involved in Regulatory T Cell Functionality.

Rosalie W M Kempkes, Irma Joosten, Hans J P M Koenen, Xuehui He

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04436419 (Immunometabolic Effects of Non-drug Strategies in the Clinical Management of Obesity), which is not on this map. Cited by 132 papers.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04436419 nacompletednot on this map

Immunometabolic Effects of Non-drug Strategies in the Clinical Management of Obesity: Translational Study

TypeinterventionalSponsorFauquéRan2018 to 2020Enrolled40ConditionsObesity, Obesity, Abdominal, Obesity, Visceral, FemaleArmsAlpha lipoic acid (plus full hospitalization), Placebo (full hospitalization: dietary monitoring with an adapted physical activity program)
3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 206 citations in OpenAlex.

  1. Review
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  13. Sepsis and the immunometabolic inflammatory response.npj metabolic health and disease · 2026
    Review
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  19. Review
  20. Metabolic reprogramming and plasticity of cancer stem cells.Frontiers in cell and developmental biology · 2026
    Review

72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rosalie W M KempkesLaboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Irma JoostenLaboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Hans J P M KoenenLaboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Xuehui HeLaboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Radboud University Nijmegen · NLRadboud University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T cells (Treg) are well-known for their immune regulatory potential and are essential for maintaining immune homeostasis. The rationale of Treg-based immunotherapy for treating autoimmunity and transplant rejection is to tip the immune balance of effector T cell-mediated immune activation and Treg-mediated immune inhibition in favor of Treg cells, either through endogenous Treg expansion strategies or adoptive transfer of

Indexed as

AnimalsHumansImmune ToleranceMetabolic Networks and PathwaysT-Lymphocytes, RegulatoryFOXP3human Treg cellsmetabolismmigrationproliferationsuppressive functiontolerance-inducing therapies

Identifiers

PMID31849995
PMCPMC6902900
OpenAlexW2993430745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.