Evidence map›Paper›PMID 31849969›Full record

ArticleFrontiers in immunology2019

Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection.

Michelle L D'Antoni, Kalpana J Kallianpur, Thomas A Premeaux, Michael J Corley, Tsuyoshi Fujita, Elizabeth I Laws, Debra Ogata-Arakaki, Dominic C Chow, Vedbar S Khadka, Cecilia M Shikuma and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Michelle L D'AntoniDepartment of Tropical Medicine, University of Hawai'i, Honolulu, HI, United States.
Kalpana J KallianpurDepartment of Tropical Medicine, University of Hawai'i, Honolulu, HI, United States.
Thomas A PremeauxDepartment of Tropical Medicine, University of Hawai'i, Honolulu, HI, United States.
Michael J CorleyDepartment of Native Hawaiian Health, University of Hawai'i, Honolulu, HI, United States.
Tsuyoshi FujitaDepartment of Tropical Medicine, University of Hawai'i, Honolulu, HI, United States.
Elizabeth I LawsDepartment of Tropical Medicine, University of Hawai'i, Honolulu, HI, United States.
Debra Ogata-ArakakiHawaii Center for AIDS, University of Hawai'i, Honolulu, HI, United States.
Dominic C ChowHawaii Center for AIDS, University of Hawai'i, Honolulu, HI, United States.
Vedbar S KhadkaOffice of Biostatistics and Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI, United States.
Cecilia M ShikumaHawaii Center for AIDS, University of Hawai'i, Honolulu, HI, United States.
Lishomwa C NdhlovuDepartment of Tropical Medicine, University of Hawai'i, Honolulu, HI, United States.
University of Hawaii System · USUniversity of Hawaiʻi at Mānoa · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI HELEN C TURNER · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Benjamin C. Fogelgren · 2017 to 2026
$59.5M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Michael A. Ortega · 2017 to 2026
$21.5M
RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MOKUAU, NOREEN, SHIRAMIZU, BRUCE T · 2012 to 2018
$21.1M
The role of epigenetic transcriptional memory in monocyte-macrophage cells and cardiovascular disease riskK01HL140271 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CORLEY, MICHAEL JAY · 2018 to 2022
$788k
NHLBI NIH HHS K01 HL140271NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P20 GM113134NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

Cognitive dysfunction persists in 30-50% of chronically HIV-infected individuals despite combination antiretroviral therapy (ART). Although monocytes are implicated in poor cognitive performance, distinct biological mechanisms associated with cognitive dysfunction in HIV infection are unclear. We previously showed that a regulatory region of the

Indexed as

AdultBiomarkersCD4-CD8 RatioCD4 Lymphocyte CountCentral Nervous System DiseasesCognitive DysfunctionCohort StudiesFemaleHIV InfectionsHumansInterferon Regulatory Factor-8Interferon Regulatory FactorsMagnetic Resonance ImagingMaleMiddle AgedMonocytesBiomarkersInterferon Regulatory Factor-8Interferon Regulatory Factorsanti-retroviral therapycentral nervous systemcognitiondendritic cellsHIV-1interferonIRF-8monocytes

Identifiers

PMID31849969
PMCPMC6895026
OpenAlexW2982845809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.