Evidence map›Paper›PMID 31849949›Full record

ReviewFrontiers in immunology2019

Flow Cytometry Contributions for the Diagnosis and Immunopathological Characterization of Primary Immunodeficiency Diseases With Immune Dysregulation.

Otavio Cabral-Marques, Lena F Schimke, Edgar Borges de Oliveira, Nadia El Khawanky, Rodrigo Nalio Ramos, Basel K Al-Ramadi, Gesmar Rodrigues Silva Segundo, Hans D Ochs, Antonio Condino-Neto

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 6 countries.

Otavio Cabral-MarquesDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Lena F SchimkeDepartment of Rheumatology and Clinical Immunology, Faculty of Medicine, Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.
Edgar Borges de OliveiraImmunogenic Inc., São Paulo, Brazil.
Nadia El KhawankyDepartment of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Freiburg im Breisgau, Germany.
Rodrigo Nalio RamosINSERM U932, SiRIC Translational Immunotherapy Team, Institut Curie, Paris Sciences et Lettres Research University, Paris, France.
Basel K Al-RamadiDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
Gesmar Rodrigues Silva SegundoDepartment of Pediatrics, Federal University of Uberlandia Medical School, Uberlândia, Brazil.
Hans D OchsDepartment of Pediatrics, University of Washington School of Medicine, and Seattle Children's Research Institute, Seattle, WA, United States.
Antonio Condino-NetoDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRInserm · FRSeattle Children's Hospital · USSouth Australian Health and Medical Research Institute · AUUnited Arab Emirates University · AEUniversidade Federal de Uberlândia · BRUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Almost 70 years after establishing the concept of primary immunodeficiency disorders (PIDs), more than 320 monogenic inborn errors of immunity have been identified thanks to the remarkable contribution of high-throughput genetic screening in the last decade. Approximately 40 of these PIDs present with autoimmune or auto-inflammatory symptoms as the primary clinical manifestation instead of infections. These PIDs are now recognized as diseases of immune dysregulation. Loss-of function mutations in genes such as

Indexed as

AnimalsAutoimmunityCell SeparationFlow CytometryHumansImmunologic Deficiency SyndromesImmunophenotypingdiagnosisflow cytometryimmune dysregulationmutationprimary immunodeficiency diseases

Identifiers

PMID31849949
PMCPMC6889851
OpenAlexW2990436173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.