Evidence map›Paper›PMID 31849906›Full record

ArticleFrontiers in microbiology2019

Physiology and Transcriptional Analysis of (p)ppGpp-Related Regulatory Effects in

Matthias Ruwe, Marcus Persicke, Tobias Busche, Benjamin Müller, Jörn Kalinowski

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Suppressor analysis inFrontiers in microbiology · 2026
    Article
  2. Response surface-based media optimization for astaxanthin production inFrontiers in bioengineering and biotechnology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthias RuweMicrobial Genomics and Biotechnology, Center for Biotechnology, Bielefeld University, Bielefeld, Germany.
Marcus PersickeMicrobial Genomics and Biotechnology, Center for Biotechnology, Bielefeld University, Bielefeld, Germany.
Tobias BuscheMicrobial Genomics and Biotechnology, Center for Biotechnology, Bielefeld University, Bielefeld, Germany.
Benjamin MüllerBiofidus AG, Bielefeld, Germany.
Jörn KalinowskiMicrobial Genomics and Biotechnology, Center for Biotechnology, Bielefeld University, Bielefeld, Germany.
Bielefeld University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The alarmone species ppGpp and pppGpp are elementary components of bacterial physiology as they both coordinate the bacterial stress response and serve as fine-tuners of general metabolism during conditions of balanced growth. Since the regulation of (p)ppGpp metabolism and the effects of (p)ppGpp on cellular processes are highly complex and show massive differences between bacterial species, the underlying molecular mechanisms have so far only been insufficiently investigated for numerous microorganisms. In this study, (p)ppGpp physiology in the actinobacterial model organism

Indexed as

discriminator(p)ppGpppromoterRelstress responsestringent response

Identifiers

PMID31849906
PMCPMC6892785
OpenAlexW2987579886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.