Evidence map›Paper›PMID 31849864›Full record

ArticleFrontiers in microbiology2019

Vasoactive Intestinal Peptide Deficiency Is Associated With Altered Gut Microbiota Communities in Male and Female C57BL/6 Mice.

Manpreet Bains, Caleb Laney, Annie E Wolfe, Megan Orr, James A Waschek, Aaron C Ericsson, Glenn P Dorsam

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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  15. The gut microbiome of laboratory mice: considerations and best practices for translational research.Mammalian genome : official journal of the International Mammalian Genome Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Manpreet BainsDepartment of Microbiological Sciences, College of Agriculture, Food Systems and Natural Resources, North Dakota State University, Fargo, ND, United States.
Caleb LaneyDepartment of Microbiological Sciences, College of Agriculture, Food Systems and Natural Resources, North Dakota State University, Fargo, ND, United States.
Annie E WolfeMetagenomics Center, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States.
Megan OrrDepartment of Statistics, College of Science and Math, North Dakota State University, Fargo, ND, United States.
James A WaschekIntellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior/Neuropsychiatric Institute, University of California, Los Angeles, Los Angeles, CA, United States.
Aaron C EricssonMetagenomics Center, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States.
Glenn P DorsamDepartment of Microbiological Sciences, College of Agriculture, Food Systems and Natural Resources, North Dakota State University, Fargo, ND, United States.
North Dakota State University · USUniversity of Missouri · USUniversity of California, Los Angeles · US

Funding

The Mutant Mouse Resource and Research Center at the University of Missouri - ResourceU42OD010918 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI James Amos-Landgraf · 2012 to 2026
$25.1M
Targeting CLEC-2/podoplanin as a therapeutic strategy for pancreatic cancerP20GM109024 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Megan Orr · 2016 to 2026
$20.5M
Impact of gut microbiota and segmented filamentous bacteria on colitis-associated colorectal cancerK01OD019924 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI ERICSSON, AARON · 2016 to 2020
$573k
NIGMS NIH HHS P20 GM109024NIH HHS K01 OD019924NIH HHS U42 OD010918
6 · The paper itself

Abstract

Vasoactive intestinal peptide (VIP) is crucial for gastrointestinal tract (GIT) health. VIP sustains GIT homeostasis through maintenance of the intestinal epithelial barrier and acts as a potent anti-inflammatory mediator that contributes to gut bacterial tolerance. Based on these biological functions by VIP, we hypothesized that its deficiency would alter gut microbial ecology. To this end, fecal samples from male and female VIP

Indexed as

Crohn’s diseasegastrointesinal tractinflammatory bowel diseaseintestinal epithelial barrierintestinal epithelial cellsmicrobiomeneuropeptideobesity

Identifiers

PMID31849864
PMCPMC6900961
OpenAlexW2991172476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.