ReviewFrontiers in physiology2019
Brain Activity Underlying Muscle Relaxation.
Review in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Pooled it
- Effects of Physical Exercise on Neuroplasticity and Brain Function: A Systematic Review in Human and Animal Studies.Neural plasticity · 2020Pooled it
- The interactive effects of biological sex and skeletal muscle fiber properties on knee-extensor muscle relaxation induced by TMS in unfatigued and fatigued states.European journal of applied physiology · 2026Article
- Surface Electromyography Characteristics of Pelvic Floor Muscles in Healthy Women, Pelvic Floor Dyssynergia, and Urinary Incontinence: A Retrospective Comparative Study.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Stopping Muscle Contractions and Relaxations during Action Inhibition Involves Global and Targeted Control Dependent on Muscle State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Effects of Imagination on Performance in Ballet: A Case Study.Sports (Basel, Switzerland) · 2025Article
- Dual-filament regulation of relaxation in mammalian fast skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Differential Cortical and Subcortical Activations during Different Stages of Muscle Control: A Functional Magnetic Resonance Imaging Study.Brain sciences · 2024Article
- The Effect of Skeletal Muscle-Pump on Blood Pressure and Postural Control in Parkinson's Disease.Cardiovascular engineering and technology · 2023Article
- The effect of initiation prediction and non-prediction on muscle relaxation control.Journal of physical therapy science · 2023Article
- Rate control deficits during pinch grip and ankle dorsiflexion in early-stage Parkinson's disease.PloS one · 2023Article
- Motor cortex excitability is reduced during freezing of upper limb movement in Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Effect of Parkinson's Disease on Cardio-postural Coupling During Orthostatic Challenge.Frontiers in physiology · 2022Article
- Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit.Nature communications · 2021Article
- Quantification of Inter-Limb Symmetries With Rate of Force Development and Relaxation Scaling Factor.Frontiers in physiology · 2021Article
- The Rolf Method of Structural Integration and Pelvic Floor Muscle Facilitation: Preliminary Results of a Randomized, Interventional Study.Journal of clinical medicine · 2020Article
- On Stopping Voluntary Muscle Relaxations and Contractions: Evidence for Shared Control Mechanisms and Muscle State-Specific Active Breaking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fine motor control of not only muscle contraction but also muscle relaxation is required for appropriate movements in both daily life and sports. Movement disorders such as Parkinson's disease and dystonia are often characterized by deficits of muscle relaxation. Neuroimaging and neurophysiological studies suggest that muscle relaxation is an active process requiring cortical activation, and not just the cessation of contraction. In this article, we review the neural mechanisms of muscle relaxation, primarily utilizing research involving transcranial magnetic stimulation (TMS). Several studies utilizing single-pulse TMS have demonstrated that, during the relaxation phase of a muscle, the excitability of the corticospinal tract controlling that particular muscle is more suppressed than in the resting condition. Other studies, utilizing paired-pulse TMS, have shown that the intracortical inhibition is activated just before muscle relaxation. Moreover, muscle relaxation of one body part suppresses cortical activities controlling other body parts in different limbs. Therefore, the cortical activity might not only be a trigger for muscle relaxation of the target muscles but could also bring about an inhibitory effect on other muscles. This spread of inhibition can hinder the appropriate contraction of muscles involved in multi-limb movements such as those used in sports and the play of musical instruments. This may also be the reason why muscle relaxation is so difficult for beginners, infants, elderly, and the cognitively impaired.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.