Evidence map›Paper›PMID 31849658›Full record

ArticleFrontiers in pharmacology2019

Antiproliferative and Immunoregulatory Effects of Azelaic Acid Against Acute Myeloid Leukemia

Zhang Dongdong, Yanxia Jin, Tian Yang, Qian Yang, Balu Wu, Yanling Chen, Ziyi Luo, Li Liang, Yunjiao Liu, Anjie Xu and 12 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Extracts of the Algerian FungusJournal of fungi (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
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  11. Review
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  13. Article
  14. Article
  15. Article
  16. Structural andEvidence-based complementary and alternative medicine : eCAM · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Zhang DongdongDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Yanxia JinDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Tian YangDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Qian YangDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Balu WuDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Yanling ChenDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Ziyi LuoDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Li LiangKey Laboratory of Artificial Micro- and Naso-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, China.
Yunjiao LiuState Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China.
Anjie XuDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Xiqin TongDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Can CanDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Lu DingDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Honglei TuDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Yuxin TanDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Hongqiang JiangDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Xiaoyan LiuDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Hui ShenDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Li LiuDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Yunbao PanDepartment of Laboratory Medicine, Zhongnan Hospital, Wuhan University, Wuhan, China.
Yongchang WeiDepartment of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Fuling ZhouDepartment of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a common type of hematological malignancy that can progress rapidly. AML has a poor prognosis and a high incidence of relapse due to therapeutic resistance. Azelaic acid (AZA), a small molecular compound is known to exhibit antitumor effect on various tumor cells. This study aimed to evaluate the antiproliferative and immunoregulatory effects of AZA against AML

Indexed as

acute myeloid leukemiaazelaic acidimmunoregulatoryNotch agonistNotch signaling pathway

Identifiers

PMID31849658
PMCPMC6901913

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.