ArticleFrontiers in behavioral neuroscience2019
Differential Effects of Serotonin Transporter Genotype on Anxiety-Like Behavior and Cognitive Judgment Bias in Mice.
Article in Frontiers in behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Effects of enrichment removal on cognitive judgement bias of mice: a comparison of two paradigms.Frontiers in veterinary science · 2026Article
- Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber.Scientific reports · 2025Article
- A rodent model of enhanced anticipation of positive events: sex-specific modifications in cognitive bias and emotional resilience.Frontiers in behavioral neuroscience · 2025Article
- The effects of Arabian jasmine on zebrafish behavior depends on strain, sex, and personality.PloS one · 2025Article
- The power of a touch: Regular touchscreen training but not its termination affects hormones and behavior in mice.Frontiers in behavioral neuroscience · 2023Article
- Behavioral lateralization of mice varying in serotonin transporter genotype.Frontiers in behavioral neuroscience · 2022Article
- Review
- 5-HTT Deficiency in Male Mice Affects Healing and Behavior after Myocardial Infarction.Journal of clinical medicine · 2021Article
- Knockout serotonin transporter in rats moderates outcome and stimulus generalization.Translational psychiatry · 2021Article
- Effects of different social experiences on emotional state in mice.Scientific reports · 2020Article
- Once an optimist, always an optimist? Studying cognitive judgment bias in mice.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans, the short allele of a common polymorphism in the serotonin transporter (5-HTT) gene is associated with a higher risk to develop depression and anxiety disorders. Furthermore, individuals carrying this allele are characterized by negative judgment biases, as they tend to interpret ambiguous information in a more pessimistic way. 5-HTT knockout mice, lacking the 5-HTT gene either homo- or heterozygously, provide a widely used model organism for the study of symptoms related to human anxiety disorders. In the present study, we aimed to prove the anxiety-like phenotype of the 5-HTT mouse model, and to investigate whether 5-HTT genotype also causes differences in judgment bias. While our results confirm that homozygous 5-HTT knockout mice display highest levels of anxiety-like behavior, it was decreased in heterozygous mice. Against our expectations, we did not detect differences in the animals' judgment bias. These results indicate that at least in mice the association between 5-HTT genotype and judgment bias is not straightforward and that other factors, including multiple genes as well as environmental influences, are implicated in the modulation of judgment biases. More research is needed to gain further insights into their function as potential endophenotypes for psychopathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.