Evidence map›Paper›PMID 31849606›Full record

ArticleFrontiers in molecular neuroscience2019

Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats.

Paola Colucci, Giulia Federica Mancini, Alessia Santori, Clemens Zwergel, Antonello Mai, Viviana Trezza, Benno Roozendaal, Patrizia Campolongo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. An emerging role for microglia in stress-effects on memory.The European journal of neuroscience · 2022
    Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Paola ColucciDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Giulia Federica ManciniDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Alessia SantoriDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Clemens ZwergelDepartment of Drug Chemistry & Technologies, Sapienza University of Rome, Rome, Italy.
Antonello MaiDepartment of Drug Chemistry & Technologies, Sapienza University of Rome, Rome, Italy.
Viviana TrezzaDepartment of Science, Section of Biomedical Sciences and Technologies, University Roma Tre, Rome, Italy.
Benno RoozendaalDepartment of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.
Patrizia CampolongoDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITFondazione Santa Lucia · ITRadboud University Nijmegen · NLRoma Tre University · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human studies have consistently shown that drugs of abuse affect memory function. The psychostimulants amphetamine and the "bath salt" 3,4-methylenedioxypyrovalerone (MDPV) increase brain monoamine levels through a similar, yet not identical, mechanism of action. Findings indicate that amphetamine enhances the consolidation of memory for emotional experiences, but still MDPV effects on memory function are underinvestigated. Here, we tested the effects induced by these two drugs on generalization of fear memory and their relative neurobiological underpinnings. To this aim, we used a modified version of the classical inhibitory avoidance task, termed

Indexed as

behaviordopamineinhibitory avoidance discrimination taskmemory accuracynorepinephrinerat

Identifiers

PMID31849606
PMCPMC6895769
OpenAlexW2990831017

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.