Evidence map›Paper›PMID 31849558›Full record

ReviewBlood and lymphatic cancer : targets and therapy2019

The Evolving Role of Brentuximab Vedotin in Classical Hodgkin Lymphoma.

Catherine Lai, Adrese Michael Kandahari, Chaitra Ujjani

Open access · goldAbstract readReview
In one paragraph

Review in Blood and lymphatic cancer : targets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Catherine LaiLombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington, DC, USA.ORCID 0000-0001-8861-0281
Adrese Michael KandahariLombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington, DC, USA.ORCID 0000-0002-0010-0680
Chaitra UjjaniSeattle Cancer Care Alliance, Fred Hutchinson CRC, University of Washington, Seattle, WA, USA.
Georgetown University · USSeattle Cancer Care Alliance · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The arrival of the CD30 directed antibody-drug conjugate, brentuximab vedotin (BV), has altered the approach to patients with classical Hodgkin lymphoma. Since initial approval in 2011, BV has been extensively studied in previously untreated and relapsed/refractory patients. Treatment indications for the antibody-drug conjugate have been expanded from the previously treated population to include maintenance therapy after autologous stem cell transplantation and recently, combination with chemotherapy in newly diagnosed advanced stage patients. This article will review the evolution of BV in classical Hodgkin lymphoma, detailing the studies that led to the approved indications and discussion of recent trials in combination with chemotherapy and immunotherapy.

Indexed as

antibody-drug conjugatebrentuximab vedotinCD30classical Hodgkin lymphomaimmunotherapynovel therapies

Identifiers

PMID31849558
PMCPMC6910100
OpenAlexW2992003906

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.