ArticleJournal of experimental pharmacology2019
Effect of Bitter Melon on Spatial Memory of Rats Receiving a High-Fat Diet.
Article in Journal of experimental pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Unraveling potential neuroprotective mechanisms of herbal medicine for Alzheimer's diseases through comprehensive molecular docking analyses.Saudi journal of biological sciences · 2024Review
- The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats.Biomedicines · 2021Article
- Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMomordica charantia or bitter melon is a tropical vine of the family Cucurbitaceous widely grown in India. Its fruits have potent anti-oxidant properties due to the presence of tannins, vitamin C and flavonoids. There is much evidence it protects cognitive function and cholesterol level. In addition, there are reports of the effect of a high-fat diet (HFD)on memory. In this study, the effect of bitter melon on spatial memory in rats, following an HFD, in a water maze was examined. MATERIAL AND
methodsIn this study, 28 male Wistar rats aged 10 weeks and weighing between 180 and 250 grams were divided into four groups (N=7). Control, High-fat, High-fat + bitter melon, and bitter melon. The control group was fed a standard rat diet, whereas the high-fat groups were fed the same standard diet containing 5% cholesterol for eight weeks, and the treated group received, in addition, 1 g/kg bitter melon fruit powder in their diet, Learning and spatial memory were evaluated by using a Morris Water Maze (MWM) for a six-day period, including five days of training, the last day was the test day (probe day).
resultsThe high-fat group was fed a high-fat diet for two months, this resulted in reduced learning ability;, this group took longer and travelled a longer distance compared to the control group. However, the administration of bitter melon improved memory function only in the high-fat group.
conclusionThe administration of bitter melon improves spatial-memory performance in rats receiving an HFD.
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