Evidence map›Paper›PMID 31849534›Full record

ArticleCancer management and research2019

Long Non-Coding RNA HCP5 Facilitates Cell Invasion And Epithelial-Mesenchymal Transition In Oral Squamous Cell Carcinoma By miR-140-5p/SOX4 Axis.

Jianling Zhao, Xijing Bai, Chong Feng, Xinhua Shang, Yuli Xi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

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  9. Molecular Pathogenesis of the Coronin Family:International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Jianling Zhao *Experimental Center of Dental Hospital Affiliated to Jiamusi University, Jiamusi City 154002, Heilongjiang Province, People's Republic of China.
Xijing Bai *Department of Oral and Maxillofacial Surgery, Tianjin Stomatology Hospital, Tianjin City 300041, People's Republic of China.
Chong FengDepartment of Orthodontics, Tianjin Stomatology Hospital, Tianjin City 300041, People's Republic of China.
Xinhua ShangBinhu Outpatient Department, Hefei Stomatological Hospital, Hefei City 230001, Anhui Province, People's Republic of China.
Yuli XiDepartment of Stomatology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang City 157000, Heilongjiang Province, People's Republic of China.
Jiamusi University · CNMudanjiang Medical University · CNStomatology Hospital · CNTianjin Stomatological Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral squamous cell carcinoma (OSCC) is the predominant histological type of human oral cancer. In this study, we sought to investigate the functional role of lncRNA HCP5 in OSCC progression.

methodsThe HCP5 and miR-140-5p expression level was determined in 73 paired OSCC tissues and their adjacent normal tissues. Knockdown or overexpression of HCP5 was conducted to investigate the effects of HCP5 on malignant behaviors of OSCC cells. Then, bioinformatic prediction and dual-luciferase reporter assay were conducted to study the interaction between HCP5 and miR-140-5p in OSCC.

resultsOur results demonstrated that HCP5 expression was significantly increased in OSCC tissues and cell lines. High HCP5 level was associated with the aggressive clinicopathological characteristics and poor prognosis of OSCC patients. In vitro gain- and loss-of-function experiments showed that HCP5 overexpression promoted, whereas HCP5 knockdown inhibited the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of OSCC cells. Mechanistically, we confirmed that HCP5 might serve as a competitive endogenous RNA (ceRNA) for miR-140-5p to alleviate the repression of its downstream target, SOX4, a master regulator of EMT. Furthermore, restoration of miR-140-5p expression diminished the oncogenic effects of HCP5 on OSCC cells.

conclusionOverall, the present study indicated that HCP5/miR-140-5p/SOX4 axis might be a ponderable and promising therapeutic target for OSCC.

Indexed as

competitive endogenous RNAepithelial-mesenchymal transitionlong non-coding RNA HCP5oral squamous cell carcinoma

Identifiers

PMID31849534
PMCPMC6913263
OpenAlexW2995327902

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.