ReviewInternational journal of nephrology and renovascular disease2019
The Importance of Tubular Function in Chronic Kidney Disease.
Review in International journal of nephrology and renovascular disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- Tubular secretion in chronic kidney disease: from established physiology to clinical utility.Frontiers in cell and developmental biology · 2026Review
- Structures and membrane interactions of human OAT1 in complex with clinical used drugs.Science advances · 2025Article
- Low-dose methotrexate adverse reaction risk in renal impairment: pharmacovigilance and physiological pharmacokinetic model assessment.Frontiers in pharmacology · 2025Article
- Modeling Metformin and Dapagliflozin Pharmacokinetics in Chronic Kidney Disease.The AAPS journal · 2024Article
- 3D vascularised proximal tubules-on-a-multiplexed chip model for enhanced cell phenotypes.Lab on a chip · 2023Article
- Therapeutic roles of thiazides and loop diuretics in blood pressure control and renal protection against chronic kidney disease.Clinical hypertension · 2023Review
- High-fat diet-induced mitochondrial dysfunction is associated with loss of protection from ischemic preconditioning in renal ischemia reperfusion.Pflugers Archiv : European journal of physiology · 2023Article
- Insights into the structure and function of the human organic anion transporter 1 in lipid bilayer membranes.Scientific reports · 2022Article
- Changes in the Expression of Renal Brush Border MembraneBiomolecules · 2021Article
- Kidney-gut crosstalk in renal disease.Irish journal of medical science · 2021Review
- Evaluation of transporter expression in HK-2 cells after exposure to free and ester-bound 3-MCPD.Toxicology reports · 2021Article
- Effects of Ischemia-Reperfusion on Tubular Cell Membrane Transporters and Consequences in Kidney Transplantation.Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glomerular filtration rate (GFR) and proteinuria-albuminuria are the renal functional parameters currently used to evaluate chronic kidney disease (CKD) severity. However, tubular secretion is another important renal functional parameter to be taken into account since proximal tubule (PT) secretion, in particular, is a crucial renal mechanism for endogenous organic cations, anions and drug elimination. The residual diuresis is a relevant survival predictor in patients on dialysis, since their urine is produced by the glomerular and tubular functions. It has been hypothesized that drugs which up-regulate some renal tubular transporters could contribute to uremic toxin excretion, and nephroprevention. However, if tubular transporters' down-regulation observed in CKD patients and experimental models is a PT adaptation to avoid intracellular accumulation and damage from uremic toxins, consequently the increase of toxin removal by inducing tubular transporters' up-regulation could be deleterious to the kidney. Therefore, a deeper understanding of this phenomenon is currently needed. In conclusion, tubular function has an important role for endogenous organic cations, anions and drug excretion in CKD patients, and a deeper understanding of its multiple mechanisms could provide new therapeutic alternatives in this population.
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