Evidence map›Paper›PMID 31849451›Full record

ArticleDrug design, development and therapy2019

In Silico, Cytotoxic and Antioxidant Potential of Novel Ester, 3-hydroxyoctyl -5

Sajid Hussain, Farhat Ullah, Muhammad Ayaz, Syed Adnan Ali Shah, Azhar-Ul-Haq Ali Shah, Syed Majid Shah, Abdul Wadood, Waqar Aman, Riaz Ullah, Abdelaaty A Shahat and 1 more

Abstract read
In one paragraph

Article in Drug design, development and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Chemical Composition and Nutritional Value of ThreeInternational journal of food science · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Hepatoprotective Effects of (-) Epicatechin in CClEvidence-based complementary and alternative medicine : eCAM · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sajid HussainDepartment of Pharmacy, University of Malakand, Malakand, Pakistan.
Farhat UllahDepartment of Pharmacy, University of Malakand, Malakand, Pakistan.
Muhammad AyazDepartment of Pharmacy, University of Malakand, Malakand, Pakistan.ORCID 0000-0002-4299-2445
Syed Adnan Ali ShahResearch Institute of Natural Products for Drug Discovery (RiND), Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Shah Alam, Malaysia.ORCID 0000-0002-8142-5013
Azhar-Ul-Haq Ali ShahDepartment of Chemistry, Kohat University of Science & Technology, Kohat, Pakistan.
Syed Majid ShahDepartment of Pharmacy, University of Malakand, Malakand, Pakistan.
Abdul WadoodDepartment of Biochemistry, Abdul Wali Khan University Mardan, Mardan, Pakistan.
Waqar AmanDepartment of Pharmacy, Kohat University of Science & Technology, Kohat, Pakistan.
Riaz UllahDepartment of Pharmacognosy (Medicinal Aromatic and Poisonous Plants Research Center), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Abdelaaty A ShahatDepartment of Pharmacognosy (Medicinal Aromatic and Poisonous Plants Research Center), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-0456-3196
Fahd A NasrDepartment of Pharmacognosy (Medicinal Aromatic and Poisonous Plants Research Center), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-6496-7822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer is one of the chronic health conditions worldwide. Various therapeutically active compounds from medicinal plants were the current focus of this research in order to uncover a treatment regimen for cancer.

methodsIn the current study, new ester 3-hydroxyoctyl -5-

resultsThe structure of the compound was elucidated based on IR, EI, and NMR spectroscopy technique. It exhibited a considerable cytotoxic effect against HepG-2 cell lines with IC

conclusionOur findings led to the isolation of a new compound from

Indexed as

AnimalsAntineoplastic Agents, PhytogenicAntioxidantsBenzothiazolesBiphenyl CompoundsBoraginaceaeCell ProliferationChlorocebus aethiopsComputer SimulationDose-Response Relationship, DrugDrug Screening Assays, AntitumorEstersFatty Acids, MonounsaturatedHep G2 CellsHumansMolecular Docking Simulation1,1-diphenyl-2-picrylhydrazyl2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidAntineoplastic Agents, PhytogenicAntioxidantsBenzothiazolesBiphenyl CompoundsEstersFatty Acids, MonounsaturatedPicratesSulfonic Acids3-hydroxyoctyl-5Anchusa arvensisantioxidantcancercytotoxicity against HepG-2 cell linestrans-docosenoate

Identifiers

PMID31849451
PMCPMC6911335

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.