Evidence map›Paper›PMID 31849424›Full record

ArticleVeterinary world2019

The potency of chitosan-based

Annise Proboningrat, Amaq Fadholly, Regina Purnama Dewi Iskandar, Agung Budianto Achmad, Fedik Abdul Rantam, Sri Agus Sudjarwo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary world, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Stem bark ethanolic extract ofOpen veterinary journal · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Annise ProboningratDoctoral Student, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.
Amaq FadhollyDoctoral Student, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.
Regina Purnama Dewi IskandarDoctoral Student, Faculty of Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.
Agung Budianto AchmadDepartment of Health, Faculty of Vocational Studies, Universitas Airlangga, Surabaya 60115, Indonesia.
Fedik Abdul RantamDepartment of Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.
Sri Agus SudjarwoDepartment of Pharmacology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimCervical cancer accounts for the fourth as a cause of death from cancer in women worldwide, with more than 85% of events and deaths occurring in developing countries. The main problems of chemotherapy are the lack of selectivity and drug resistance. This study aimed to investigate the signal transduction of chitosan-based MATERIALS AND

methodsNano-PMBE was prepared based on the ionic gelation method. Its anticancer activities in HeLa cells were investigated through cytotoxicity test, cell cycle, and apoptosis analysis. The expression of p53 and caspase-9 was also observed.

resultsThe results showed that Nano-PMBE has a size of 394.3 nm. Meanwhile, the Nano-PMBE was cytotoxic to HeLa cells (IC

conclusionThe results showed a notable anticancer effect of Nano-PMBE by arresting the cell cycle and inducing apoptosis in HeLa cells, suggesting that it might have therapeutic potential for cervical cancer. Further research is needed to find out more about the anticancer mechanism of Nano-PMBE in HeLa cells to

Indexed as

chitosanHeLa cellsnanoparticlesPinus merkusii

Identifiers

PMID31849424
PMCPMC6868265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.