ArticleJournal of biomedical optics2019
Opto-acoustic imaging of relative blood oxygen saturation and total hemoglobin for breast cancer diagnosis.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Blood-mimicking dye phantoms for evaluating photoacoustic oximetry accuracy.Photoacoustics · 2026Article
- Advances in Photoacoustic Imaging of Breast Cancer.Sensors (Basel, Switzerland) · 2025Review
- Anthropomorphic tissue-mimicking phantoms for oximetry validation in multispectral optical imaging.Journal of biomedical optics · 2025Article
- Photoacoustic imaging of rat kidney tissue oxygenation using second near-infrared wavelengths.Journal of biomedical optics · 2025Article
- The role of molecular imaging in detecting fibrosis in Crohn's disease.Annals of medicine · 2024Review
- Quantitative photoacoustic tomography: modeling and inverse problems.Journal of biomedical optics · 2024Review
- Spectral crosstalk in photoacoustic computed tomography.Photoacoustics · 2022Article
- Photoacoustic imaging of fresh human surgically and endoscopically resected gastrointestinal specimens.DEN open · 2022Article
- Optical Resolution Photoacoustic Microscopy Imaging in the Detection of Early Oral Cancer under Image Reconstruction Algorithm.Computational and mathematical methods in medicine · 2022Article
- Suite of 3D test objects for performance assessment of hybrid photoacoustic-ultrasound breast imaging systems.Journal of biomedical optics · 2021Article
- Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment.Journal of biomedical optics · 2021Review
- Molecular Imaging of Inflammatory Disease.Biomedicines · 2021Review
- Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opto-acoustic imaging involves using light to produce sound waves for visualizing blood in biological tissue. By using multiple optical wavelengths, diagnostic images of blood oxygen saturation and total hemoglobin are generated using endogenous optical contrast, without injection of any external contrast agent and without using any ionizing radiation. The technology has been used in recent clinical studies for diagnosis of breast cancer to help distinguish benign from malignant lesions, potentially reducing the need for biopsy through improved diagnostic imaging accuracy. To enable this application, techniques for mapping oxygen saturation differences within tissue are necessary. Using biologically relevant opto-acoustic phantoms, we analyze the ability of an opto-acoustic imaging system to display colorized parametric maps that are generated using a statistical mapping approach. To mimic breast tissue, a material with closely matching properties for optical absorption, optical scattering, acoustic attenuation, and speed of sound is used. The phantoms include two vessels filled with whole blood at oxygen saturation levels determined using a sensor-based approach. A flow system with gas-mixer and membrane oxygenator adjusts the oxygen saturation of each vessel independently. Datasets are collected with an investigational Imagio
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.