Evidence map›Paper›PMID 31849039›Full record

ArticleImmunology2020

Identification of an HLA-A*24:02-restricted α-fetoprotein signal peptide-derived antigen and its specific T-cell receptor for T-cell immunotherapy.

Zhenjuan Li, Haiping Gong, Qiuping Liu, Wanli Wu, Jianting Cheng, Yingyi Mei, Yaolong Chen, Hongjun Zheng, Xiaohong Yu, Shi Zhong and 1 more

Open access · greenAbstract read
In one paragraph

Article in Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?International journal of biological sciences · 2022
    Review
  8. Cellular based immunotherapy for primary liver cancer.Journal of experimental & clinical cancer research : CR · 2021
    Review
  9. Review
  10. Review
  11. [Carcinoembryonic type specific markers and liver cancer immunotherapy].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zhenjuan LiSchool of Life Sciences, University of Science and Technology of China, Hefei, China.ORCID 0000-0003-0037-6596
Haiping GongGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.
Qiuping LiuGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.
Wanli WuGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.
Jianting ChengGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.
Yingyi MeiGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.
Yaolong ChenGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.
Hongjun ZhengGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.
Xiaohong YuGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.
Shi ZhongGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.
Yi LiGuangdong Xiangxue Life Sciences, Ltd., Guangzhou, China.ORCID 0000-0002-7068-0019
Jinan University · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the most common type of liver cancer with limited treatments. Asia has the highest HCC incidence rates; China accounts for over 50% of all HCC cases worldwide. T-cell receptor (TCR) -engineered T-cell immunotherapies specific for human leukocyte antigen (HLA) -A*02:01-restricted α-fetoprotein (AFP) peptide have shown encouraging results in clinics. HLA-A*24:02 is more common than HLA-A*02:01 in Asian countries, including China. Here we identified a novel HLA-A*24:02-restricted peptide KWVESIFLIF (AFP

Indexed as

alpha-FetoproteinsAmino Acid SequenceAntigens, NeoplasmBinding SitesCarcinoma, HepatocellularCell Line, TumorCoculture TechniquesGene ExpressionHealthy VolunteersHep G2 CellsHLA-A24 AntigenHumansImmunotherapyLiver NeoplasmsOligopeptidesProtein BindingAFP protein, humanalpha-FetoproteinsAntigens, NeoplasmHLA-A*24:02 antigenHLA-A24 AntigenOligopeptidesProtein Sorting SignalsReceptors, Antigen, T-Cellhepatocellular carcinomaHLA-A*24:02mass spectrometryT-cell immunotherapyα-fetoprotein

Identifiers

PMID31849039
PMCPMC7078006
OpenAlexW2996376509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.